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Prospective Study to Assess Progression of Renal Markers after Interruption of Tenofovir due to Nephrotoxicity
Joint Authors
Echeverría, Patricia
Estany, Carla
Clotet, Bonaventura
Negredo, Eugenia
Bonjoch, Anna
Puig, Jordi
Pérez-Alvarez, Nuria
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-18
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Prospective studies about the reversibility of tenofovir disoproxil fumarate- (TDF-) related renal impairment remain scarce.
Methods.
This is an observational prospective study including all patients that presented at our HIV Unit who interrupted TDF owing to nephrotoxicity.
We assessed the evolution of renal parameters after discontinuation of this drug.
Results.
We included 59 patients, who were followed up for 72 weeks.
Most were male (41, 69.5%), median (IQR) age was 53 (44; 58) years, and median time receiving TDF-containing regimens was 55.4 (28; 87.7) months.
Most patients were receiving PI-based treatments (67%).
At the final visit, most of the subjects showed complete recovery (35, 59.3%) or improvement (13 subjects, 22%).
Significant improvements were observed in creatinine levels (from 84.9 [73.8; 97.5] to 78 [69.6; 91] μmol/L, p=0.013), estimated glomerular filtration rate (eGFR, CKD EPI equation, from 87.7 [67; 99] to 89.9 [73.6; 99.3] mL/min/1.73 m2, p=0.017), and number of patients with eGFR <60 mL/min/1.73 m2 (from 9 [15.3%] to 1 [1.7%], p=0.031).
A trend toward significance was observed in abnormal urine proteinuria/creatinine ratio (from 22 [37%] to 8 [13.6%], p=0.057).
Conclusions.
Our results corroborate the high frequency of complete or partial renal recovery in patients receiving TDF-containing regimens who discontinued therapy owing to nephrotoxicity.
American Psychological Association (APA)
Bonjoch, Anna& Echeverría, Patricia& Pérez-Alvarez, Nuria& Puig, Jordi& Estany, Carla& Clotet, Bonaventura…[et al.]. 2016. Prospective Study to Assess Progression of Renal Markers after Interruption of Tenofovir due to Nephrotoxicity. BioMed Research International،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1097786
Modern Language Association (MLA)
Bonjoch, Anna…[et al.]. Prospective Study to Assess Progression of Renal Markers after Interruption of Tenofovir due to Nephrotoxicity. BioMed Research International No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1097786
American Medical Association (AMA)
Bonjoch, Anna& Echeverría, Patricia& Pérez-Alvarez, Nuria& Puig, Jordi& Estany, Carla& Clotet, Bonaventura…[et al.]. Prospective Study to Assess Progression of Renal Markers after Interruption of Tenofovir due to Nephrotoxicity. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1097786
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097786