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Estrogen Modulates Expression of Tight Junction Proteins in Rat Vagina
المؤلفون المشاركون
Lee, Hyun-Suk
Park, Kwangsung
Oh, Kyung-Jin
Ahn, Kyuyoun
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-05
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
The objectives of this study were to investigate the localization of tight junctions and the modulation of zonula occludens- (ZO-) 1, occludin and claudin-1 expression by estrogen in castrated female rat vagina.
Female Sprague-Dawley rats (230–240 g, n = 45 ) were divided into three groups and subjected to a sham operation (control group, n = 15 ), bilateral ovariectomy (Ovx group, n = 15 ), or bilateral ovariectomy followed by daily subcutaneous injection of 17β-estradiol (50 μg/kg/day, Ovx + Est group, n = 15 ).
The cellular localization and expression of ZO-1, occludin, and claudin-1 were determined in each group by immunohistochemistry and western blot.
Results.
Expression of ZO-1 was diffuse in all groups, with the highest intensity in the superficial epithelium in the control group.
Occludin was localized in the intermediate and basal epithelium.
Claudin-1 was most intense in the superficial layer of the vaginal epithelium in the control group.
Expression of ZO-1, occludin, and claudin-1 was significantly decreased after ovariectomy and was restored to the level of the control after estrogen replacement.
Conclusions.
Tight junctions are distinctly localized in rat vagina, and estrogen modulates the expression of tight junctions.
Further researches are needed to clarify the functional role of tight junctions in vaginal lubrication.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Oh, Kyung-Jin& Lee, Hyun-Suk& Ahn, Kyuyoun& Park, Kwangsung. 2016. Estrogen Modulates Expression of Tight Junction Proteins in Rat Vagina. BioMed Research International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1097791
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Oh, Kyung-Jin…[et al.]. Estrogen Modulates Expression of Tight Junction Proteins in Rat Vagina. BioMed Research International No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1097791
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Oh, Kyung-Jin& Lee, Hyun-Suk& Ahn, Kyuyoun& Park, Kwangsung. Estrogen Modulates Expression of Tight Junction Proteins in Rat Vagina. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1097791
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1097791
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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