Positive Selection and Centrality in the Yeast and Fly Protein-Protein Interaction Networks
المؤلفون المشاركون
Chakraborty, Sandip
Alvarez-Ponce, David
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-28
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Proteins within a molecular network are expected to be subject to different selective pressures depending on their relative hierarchical positions.
However, it is not obvious what genes within a network should be more likely to evolve under positive selection.
On one hand, only mutations at genes with a relatively high degree of control over adaptive phenotypes (such as those encoding highly connected proteins) are expected to be “seen” by natural selection.
On the other hand, a high degree of pleiotropy at these genes is expected to hinder adaptation.
Previous analyses of the human protein-protein interaction network have shown that genes under long-term, recurrent positive selection (as inferred from interspecific comparisons) tend to act at the periphery of the network.
It is unknown, however, whether these trends apply to other organisms.
Here, we show that long-term positive selection has preferentially targeted the periphery of the yeast interactome.
Conversely, in flies, genes under positive selection encode significantly more connected and central proteins.
These observations are not due to covariation of genes’ adaptability and centrality with confounding factors.
Therefore, the distribution of proteins encoded by genes under recurrent positive selection across protein-protein interaction networks varies from one species to another.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chakraborty, Sandip& Alvarez-Ponce, David. 2016. Positive Selection and Centrality in the Yeast and Fly Protein-Protein Interaction Networks. BioMed Research International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1097866
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chakraborty, Sandip& Alvarez-Ponce, David. Positive Selection and Centrality in the Yeast and Fly Protein-Protein Interaction Networks. BioMed Research International No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1097866
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chakraborty, Sandip& Alvarez-Ponce, David. Positive Selection and Centrality in the Yeast and Fly Protein-Protein Interaction Networks. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1097866
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1097866
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر