Positive Selection and Centrality in the Yeast and Fly Protein-Protein Interaction Networks
Joint Authors
Chakraborty, Sandip
Alvarez-Ponce, David
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Proteins within a molecular network are expected to be subject to different selective pressures depending on their relative hierarchical positions.
However, it is not obvious what genes within a network should be more likely to evolve under positive selection.
On one hand, only mutations at genes with a relatively high degree of control over adaptive phenotypes (such as those encoding highly connected proteins) are expected to be “seen” by natural selection.
On the other hand, a high degree of pleiotropy at these genes is expected to hinder adaptation.
Previous analyses of the human protein-protein interaction network have shown that genes under long-term, recurrent positive selection (as inferred from interspecific comparisons) tend to act at the periphery of the network.
It is unknown, however, whether these trends apply to other organisms.
Here, we show that long-term positive selection has preferentially targeted the periphery of the yeast interactome.
Conversely, in flies, genes under positive selection encode significantly more connected and central proteins.
These observations are not due to covariation of genes’ adaptability and centrality with confounding factors.
Therefore, the distribution of proteins encoded by genes under recurrent positive selection across protein-protein interaction networks varies from one species to another.
American Psychological Association (APA)
Chakraborty, Sandip& Alvarez-Ponce, David. 2016. Positive Selection and Centrality in the Yeast and Fly Protein-Protein Interaction Networks. BioMed Research International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1097866
Modern Language Association (MLA)
Chakraborty, Sandip& Alvarez-Ponce, David. Positive Selection and Centrality in the Yeast and Fly Protein-Protein Interaction Networks. BioMed Research International No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1097866
American Medical Association (AMA)
Chakraborty, Sandip& Alvarez-Ponce, David. Positive Selection and Centrality in the Yeast and Fly Protein-Protein Interaction Networks. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1097866
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097866