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Cell Cycle Arrest and Apoptosis Induction via Modulation of Mitochondrial Integrity by Bcl-2 Family Members and Caspase Dependence in Dracaena cinnabari-Treated H400 Human Oral Squamous Cell Carcinoma
المؤلفون المشاركون
Alabsi, Aied Mohammed
Muharram, Bushra
Lim, Kai Li
Paterson, Ian C.
Ali-Saeed, Rola
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-30
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Dracaena cinnabari Balf.f.
is a red resin endemic to Socotra Island, Yemen.
Although there have been several reports on its therapeutic properties, information on its cytotoxicity and anticancer effects is very limited.
This study utilized a bioassay-guided fractionation approach to determine the cytotoxic and apoptosis-inducing effects of D.
cinnabari on human oral squamous cell carcinoma (OSCC).
The cytotoxic effects of D.
cinnabari crude extract were observed in a panel of OSCC cell lines and were most pronounced in H400.
Only fractions DCc and DCd were active on H400 cells; subfractions DCc15 and DCd16 exhibited the greatest cytotoxicity against H400 cells and D.
cinnabari inhibited cells proliferation in a time-dependent manner.
This was achieved primarily via apoptosis where externalization of phospholipid phosphatidylserine was observed using DAPI/Annexin V fluorescence double staining mechanism studied through mitochondrial membrane potential assay cytochrome c enzyme-linked immunosorbent and caspases activities revealed depolarization of mitochondrial membrane potential (MMP) and significant activation of caspases 9 and 3/7, concomitant with S phase arrest.
Apoptotic proteins array suggested that MMP was regulated by Bcl-2 proteins family as results demonstrated an upregulation of Bax, Bad, and Bid as well as downregulation of Bcl-2.
Hence, D.
cinnabari has the potential to be developed as an anticancer agent.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alabsi, Aied Mohammed& Lim, Kai Li& Paterson, Ian C.& Ali-Saeed, Rola& Muharram, Bushra. 2016. Cell Cycle Arrest and Apoptosis Induction via Modulation of Mitochondrial Integrity by Bcl-2 Family Members and Caspase Dependence in Dracaena cinnabari-Treated H400 Human Oral Squamous Cell Carcinoma. BioMed Research International،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1097938
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alabsi, Aied Mohammed…[et al.]. Cell Cycle Arrest and Apoptosis Induction via Modulation of Mitochondrial Integrity by Bcl-2 Family Members and Caspase Dependence in Dracaena cinnabari-Treated H400 Human Oral Squamous Cell Carcinoma. BioMed Research International No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1097938
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alabsi, Aied Mohammed& Lim, Kai Li& Paterson, Ian C.& Ali-Saeed, Rola& Muharram, Bushra. Cell Cycle Arrest and Apoptosis Induction via Modulation of Mitochondrial Integrity by Bcl-2 Family Members and Caspase Dependence in Dracaena cinnabari-Treated H400 Human Oral Squamous Cell Carcinoma. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1097938
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1097938
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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