Progressive Depletion of Rough Endoplasmic Reticulum in Epithelial Cells of the Small Intestine in Monosodium Glutamate Mice Model of Obesity
المؤلفون المشاركون
Nakadate, Kazuhiko
Motojima, Kento
Hirakawa, Tomoya
Tanaka-Nakadate, Sawako
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-29
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Chronic obesity is a known risk factor for metabolic syndrome.
However, little is known about pathological changes in the small intestine associated with chronic obesity.
This study investigated cellular and subcellular level changes in the small intestine of obese mice.
In this study, a mouse model of obesity was established by early postnatal administration of monosodium glutamate.
Changes in body weight were monitored, and pathological changes in the small intestine were evaluated using hematoxylin-eosin and Nissl staining and light and electron microscopy.
Consequently, obese mice were significantly heavier compared with controls from 9 weeks of age.
Villi in the small intestine of obese mice were elongated and thinned.
There was reduced hematoxylin staining in the epithelium of the small intestine of obese mice.
Electron microscopy revealed a significant decrease in and shortening of rough endoplasmic reticulum in epithelial cells of the small intestine of obese mice compared with normal mice.
The decrease in rough endoplasmic reticulum in the small intestine epithelial cells of obese mice indicates that obesity starting in childhood influences various functions of the small intestine, such as protein synthesis, and could impair both the defense mechanism against invasion of pathogenic microbes and nutritional absorption.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nakadate, Kazuhiko& Motojima, Kento& Hirakawa, Tomoya& Tanaka-Nakadate, Sawako. 2016. Progressive Depletion of Rough Endoplasmic Reticulum in Epithelial Cells of the Small Intestine in Monosodium Glutamate Mice Model of Obesity. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098071
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nakadate, Kazuhiko…[et al.]. Progressive Depletion of Rough Endoplasmic Reticulum in Epithelial Cells of the Small Intestine in Monosodium Glutamate Mice Model of Obesity. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1098071
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nakadate, Kazuhiko& Motojima, Kento& Hirakawa, Tomoya& Tanaka-Nakadate, Sawako. Progressive Depletion of Rough Endoplasmic Reticulum in Epithelial Cells of the Small Intestine in Monosodium Glutamate Mice Model of Obesity. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098071
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098071
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر