Progressive Depletion of Rough Endoplasmic Reticulum in Epithelial Cells of the Small Intestine in Monosodium Glutamate Mice Model of Obesity
Joint Authors
Nakadate, Kazuhiko
Motojima, Kento
Hirakawa, Tomoya
Tanaka-Nakadate, Sawako
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Chronic obesity is a known risk factor for metabolic syndrome.
However, little is known about pathological changes in the small intestine associated with chronic obesity.
This study investigated cellular and subcellular level changes in the small intestine of obese mice.
In this study, a mouse model of obesity was established by early postnatal administration of monosodium glutamate.
Changes in body weight were monitored, and pathological changes in the small intestine were evaluated using hematoxylin-eosin and Nissl staining and light and electron microscopy.
Consequently, obese mice were significantly heavier compared with controls from 9 weeks of age.
Villi in the small intestine of obese mice were elongated and thinned.
There was reduced hematoxylin staining in the epithelium of the small intestine of obese mice.
Electron microscopy revealed a significant decrease in and shortening of rough endoplasmic reticulum in epithelial cells of the small intestine of obese mice compared with normal mice.
The decrease in rough endoplasmic reticulum in the small intestine epithelial cells of obese mice indicates that obesity starting in childhood influences various functions of the small intestine, such as protein synthesis, and could impair both the defense mechanism against invasion of pathogenic microbes and nutritional absorption.
American Psychological Association (APA)
Nakadate, Kazuhiko& Motojima, Kento& Hirakawa, Tomoya& Tanaka-Nakadate, Sawako. 2016. Progressive Depletion of Rough Endoplasmic Reticulum in Epithelial Cells of the Small Intestine in Monosodium Glutamate Mice Model of Obesity. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098071
Modern Language Association (MLA)
Nakadate, Kazuhiko…[et al.]. Progressive Depletion of Rough Endoplasmic Reticulum in Epithelial Cells of the Small Intestine in Monosodium Glutamate Mice Model of Obesity. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1098071
American Medical Association (AMA)
Nakadate, Kazuhiko& Motojima, Kento& Hirakawa, Tomoya& Tanaka-Nakadate, Sawako. Progressive Depletion of Rough Endoplasmic Reticulum in Epithelial Cells of the Small Intestine in Monosodium Glutamate Mice Model of Obesity. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098071
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098071