The Association between VDR Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Systematic Review and Meta-Analysis
المؤلفون المشاركون
Zhang, Yun
Xia, Wei
Lu, Ping
Yuan, Huijuan
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-06
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Aims.
Studies on the associations of vitamin D receptor (VDR) gene polymorphisms with diabetic retinopathy (DR) susceptibility reported conflicting results.
A systematic meta-analysis was undertaken to clarify this topic.
Methods.
A systematic search of electronic databases (PubMed, EMBASE, and CNKI) was carried out until March 31, 2016.
The pooled odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of the association.
Results.
A total of 7 studies fulfilling the inclusion criteria were included in this meta-analysis (649 cases and 707 controls).
Pooled ORs showed a significant association between FokI polymorphism and DR risk in all the four genetic models (OR=1.612 (1.354~1.921), 1.988 (1.481~2.668), 1.889 (1.424~2.505), and 2.674 (1.493~4.790) in allelic, dominant, recessive, and additive models, resp., PZ<0.01), but not for TaqI or BsmI polymorphism (PZ>0.05).
Similar results were found in the subgroup analysis.
Sensitivity analysis indicated that the results were relatively stable and reliable.
Results of Begg’s and Egger’s tests suggested a lack of publication bias.
Conclusions.
Our meta-analysis demonstrated that DR was significantly associated with VDR gene FokI polymorphism.
However, due to the relatively small sample size in this meta-analysis, further studies with a larger sample size should be done to confirm the findings.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Yun& Xia, Wei& Lu, Ping& Yuan, Huijuan. 2016. The Association between VDR Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1098081
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Yun…[et al.]. The Association between VDR Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Systematic Review and Meta-Analysis. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1098081
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Yun& Xia, Wei& Lu, Ping& Yuan, Huijuan. The Association between VDR Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Systematic Review and Meta-Analysis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1098081
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098081
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر