The Association between VDR Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Systematic Review and Meta-Analysis
Joint Authors
Zhang, Yun
Xia, Wei
Lu, Ping
Yuan, Huijuan
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aims.
Studies on the associations of vitamin D receptor (VDR) gene polymorphisms with diabetic retinopathy (DR) susceptibility reported conflicting results.
A systematic meta-analysis was undertaken to clarify this topic.
Methods.
A systematic search of electronic databases (PubMed, EMBASE, and CNKI) was carried out until March 31, 2016.
The pooled odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of the association.
Results.
A total of 7 studies fulfilling the inclusion criteria were included in this meta-analysis (649 cases and 707 controls).
Pooled ORs showed a significant association between FokI polymorphism and DR risk in all the four genetic models (OR=1.612 (1.354~1.921), 1.988 (1.481~2.668), 1.889 (1.424~2.505), and 2.674 (1.493~4.790) in allelic, dominant, recessive, and additive models, resp., PZ<0.01), but not for TaqI or BsmI polymorphism (PZ>0.05).
Similar results were found in the subgroup analysis.
Sensitivity analysis indicated that the results were relatively stable and reliable.
Results of Begg’s and Egger’s tests suggested a lack of publication bias.
Conclusions.
Our meta-analysis demonstrated that DR was significantly associated with VDR gene FokI polymorphism.
However, due to the relatively small sample size in this meta-analysis, further studies with a larger sample size should be done to confirm the findings.
American Psychological Association (APA)
Zhang, Yun& Xia, Wei& Lu, Ping& Yuan, Huijuan. 2016. The Association between VDR Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1098081
Modern Language Association (MLA)
Zhang, Yun…[et al.]. The Association between VDR Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Systematic Review and Meta-Analysis. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1098081
American Medical Association (AMA)
Zhang, Yun& Xia, Wei& Lu, Ping& Yuan, Huijuan. The Association between VDR Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Systematic Review and Meta-Analysis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1098081
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098081