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Analyzing the miRNA-Gene Networks to Mine the Important miRNAs under Skin of Human and Mouse
المؤلفون المشاركون
Zhang, Wenguang
Bai, Yongsheng
Wu, Jianghong
Gong, Husile
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-05
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Genetic networks provide new mechanistic insights into the diversity of species morphology.
In this study, we have integrated the MGI, GEO, and miRNA database to analyze the genetic regulatory networks under morphology difference of integument of humans and mice.
We found that the gene expression network in the skin is highly divergent between human and mouse.
The GO term of secretion was highly enriched, and this category was specific in human compared to mouse.
These secretion genes might be involved in eccrine system evolution in human.
In addition, total 62,637 miRNA binding target sites were predicted in human integument genes (IGs), while 26,280 miRNA binding target sites were predicted in mouse IGs.
The interactions between miRNAs and IGs in human are more complex than those in mouse.
Furthermore, hsa-miR-548, mmu-miR-466, and mmu-miR-467 have an enormous number of targets on IGs, which both have the role of inhibition of host immunity response.
The pattern of distribution on the chromosome of these three miRNAs families is very different.
The interaction of miRNA/IGs has added the new dimension in traditional gene regulation networks of skin.
Our results are generating new insights into the gene networks basis of skin difference between human and mouse.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Jianghong& Gong, Husile& Bai, Yongsheng& Zhang, Wenguang. 2016. Analyzing the miRNA-Gene Networks to Mine the Important miRNAs under Skin of Human and Mouse. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098132
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Jianghong…[et al.]. Analyzing the miRNA-Gene Networks to Mine the Important miRNAs under Skin of Human and Mouse. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1098132
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Jianghong& Gong, Husile& Bai, Yongsheng& Zhang, Wenguang. Analyzing the miRNA-Gene Networks to Mine the Important miRNAs under Skin of Human and Mouse. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098132
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098132
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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