Analyzing the miRNA-Gene Networks to Mine the Important miRNAs under Skin of Human and Mouse

Joint Authors

Zhang, Wenguang
Bai, Yongsheng
Wu, Jianghong
Gong, Husile

Source

BioMed Research International

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-09-05

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Medicine

Abstract EN

Genetic networks provide new mechanistic insights into the diversity of species morphology.

In this study, we have integrated the MGI, GEO, and miRNA database to analyze the genetic regulatory networks under morphology difference of integument of humans and mice.

We found that the gene expression network in the skin is highly divergent between human and mouse.

The GO term of secretion was highly enriched, and this category was specific in human compared to mouse.

These secretion genes might be involved in eccrine system evolution in human.

In addition, total 62,637 miRNA binding target sites were predicted in human integument genes (IGs), while 26,280 miRNA binding target sites were predicted in mouse IGs.

The interactions between miRNAs and IGs in human are more complex than those in mouse.

Furthermore, hsa-miR-548, mmu-miR-466, and mmu-miR-467 have an enormous number of targets on IGs, which both have the role of inhibition of host immunity response.

The pattern of distribution on the chromosome of these three miRNAs families is very different.

The interaction of miRNA/IGs has added the new dimension in traditional gene regulation networks of skin.

Our results are generating new insights into the gene networks basis of skin difference between human and mouse.

American Psychological Association (APA)

Wu, Jianghong& Gong, Husile& Bai, Yongsheng& Zhang, Wenguang. 2016. Analyzing the miRNA-Gene Networks to Mine the Important miRNAs under Skin of Human and Mouse. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098132

Modern Language Association (MLA)

Wu, Jianghong…[et al.]. Analyzing the miRNA-Gene Networks to Mine the Important miRNAs under Skin of Human and Mouse. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1098132

American Medical Association (AMA)

Wu, Jianghong& Gong, Husile& Bai, Yongsheng& Zhang, Wenguang. Analyzing the miRNA-Gene Networks to Mine the Important miRNAs under Skin of Human and Mouse. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098132

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1098132