Identification of ITGA2B and ITGB3 Single-Nucleotide Polymorphisms and Their Influences on the Platelet Function

المؤلفون المشاركون

Xiang, Qian
Ji, Shun-Dong
Zhang, Zhuo
Zhao, Xia
Cui, Yi-Min

المصدر

BioMed Research International

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-11-14

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

الطب البشري

الملخص EN

The aim of the study was to investigate ITGA2B and ITGB3 genetic polymorphisms and to evaluate the variability in the platelet function in healthy Chinese subjects.

The genetic sequence of the entire coding region of the ITGA2B and ITGB3 genes was investigated.

Adenosine diphosphate-induced platelet aggregation, glycoprotein IIb/IIIa content, bleeding time, and coagulation indexes were detected.

Thirteen variants in the ITGA2B locus and 29 variants in the ITGB3 locus were identified in the Chinese population.

The rs1009312 and rs2015049 were associated with the mean platelet volume.

The rs70940817 was significantly correlated with the prothrombin time.

The rs70940817 and rs112188890 were related with the activated partial thromboplastin time, and ITGB3 rs4642 was correlated with the thrombin time and fibrinogen.

The minor alleles of rs56197296 and rs5919 were associated with decreased ADP-induced platelet aggregation, and rs55827077 was related with decreased GPIIb/IIIa per platelet.

The rs1009312, rs2015049, rs3760364, rs567581451, rs7208170, and rs117052258 were related with bleeding time.

Further studies are needed to explore the clinical importance of ITGA2B and ITGB3 SNPs in the platelet function.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Xiang, Qian& Ji, Shun-Dong& Zhang, Zhuo& Zhao, Xia& Cui, Yi-Min. 2016. Identification of ITGA2B and ITGB3 Single-Nucleotide Polymorphisms and Their Influences on the Platelet Function. BioMed Research International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1098161

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Xiang, Qian…[et al.]. Identification of ITGA2B and ITGB3 Single-Nucleotide Polymorphisms and Their Influences on the Platelet Function. BioMed Research International No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1098161

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Xiang, Qian& Ji, Shun-Dong& Zhang, Zhuo& Zhao, Xia& Cui, Yi-Min. Identification of ITGA2B and ITGB3 Single-Nucleotide Polymorphisms and Their Influences on the Platelet Function. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1098161

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1098161