Identification of ITGA2B and ITGB3 Single-Nucleotide Polymorphisms and Their Influences on the Platelet Function
Joint Authors
Xiang, Qian
Ji, Shun-Dong
Zhang, Zhuo
Zhao, Xia
Cui, Yi-Min
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The aim of the study was to investigate ITGA2B and ITGB3 genetic polymorphisms and to evaluate the variability in the platelet function in healthy Chinese subjects.
The genetic sequence of the entire coding region of the ITGA2B and ITGB3 genes was investigated.
Adenosine diphosphate-induced platelet aggregation, glycoprotein IIb/IIIa content, bleeding time, and coagulation indexes were detected.
Thirteen variants in the ITGA2B locus and 29 variants in the ITGB3 locus were identified in the Chinese population.
The rs1009312 and rs2015049 were associated with the mean platelet volume.
The rs70940817 was significantly correlated with the prothrombin time.
The rs70940817 and rs112188890 were related with the activated partial thromboplastin time, and ITGB3 rs4642 was correlated with the thrombin time and fibrinogen.
The minor alleles of rs56197296 and rs5919 were associated with decreased ADP-induced platelet aggregation, and rs55827077 was related with decreased GPIIb/IIIa per platelet.
The rs1009312, rs2015049, rs3760364, rs567581451, rs7208170, and rs117052258 were related with bleeding time.
Further studies are needed to explore the clinical importance of ITGA2B and ITGB3 SNPs in the platelet function.
American Psychological Association (APA)
Xiang, Qian& Ji, Shun-Dong& Zhang, Zhuo& Zhao, Xia& Cui, Yi-Min. 2016. Identification of ITGA2B and ITGB3 Single-Nucleotide Polymorphisms and Their Influences on the Platelet Function. BioMed Research International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1098161
Modern Language Association (MLA)
Xiang, Qian…[et al.]. Identification of ITGA2B and ITGB3 Single-Nucleotide Polymorphisms and Their Influences on the Platelet Function. BioMed Research International No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1098161
American Medical Association (AMA)
Xiang, Qian& Ji, Shun-Dong& Zhang, Zhuo& Zhao, Xia& Cui, Yi-Min. Identification of ITGA2B and ITGB3 Single-Nucleotide Polymorphisms and Their Influences on the Platelet Function. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1098161
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098161