Immunohistochemical Studies on Galectin Expression in Colectomised Patients with Ulcerative Colitis
المؤلفون المشاركون
Block, Mattias
Mölne, Johan
Leffler, Hakon
Börjesson, Lars
Breimer, Michael E.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-18
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Introduction.
The aetiology and pathogenesis of ulcerative colitis (UC) are essentially unknown.
Galectins are carbohydrate-binding lectins involved in a large number of physiological and pathophysiological processes.
Little is known about the role of galectins in human UC.
In this immunohistochemical exploratory study, both epithelial and inflammatory cell galectin expression were studied in patients with a thoroughly documented clinical history and were correlated with inflammatory activity.
Material and Methods.
Surgical whole intestinal wall colon specimens from UC patients ( n = 22 ) and controls ( n = 10 ) were studied.
Clinical history, pharmacological treatment, and modified Mayo-score were recorded.
Tissue inflammation was graded, and sections were stained with antibodies recognizing galectin-1, galectin-2, galectin-3, and galectin-4.
Results.
Galectin-1 was undetectable in normal and UC colonic epithelium, while galectin-2, galectin-3, and galectin-4 were strongly expressed.
A tendency towards diminished epithelial expression with increased inflammatory grade for galectin-2, galectin-3, and galectin-4 was also found.
In the inflammatory cells, a strong expression of galectin-2 and a weak expression of galectin-3 were seen.
No clear-cut correlation between epithelial galectin expression and severity of the disease was found.
Conclusion.
Galectin expression in patients with UC seems to be more dependent on disease focality and individual variation than on degree of tissue inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Block, Mattias& Mölne, Johan& Leffler, Hakon& Börjesson, Lars& Breimer, Michael E.. 2016. Immunohistochemical Studies on Galectin Expression in Colectomised Patients with Ulcerative Colitis. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1098330
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Block, Mattias…[et al.]. Immunohistochemical Studies on Galectin Expression in Colectomised Patients with Ulcerative Colitis. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1098330
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Block, Mattias& Mölne, Johan& Leffler, Hakon& Börjesson, Lars& Breimer, Michael E.. Immunohistochemical Studies on Galectin Expression in Colectomised Patients with Ulcerative Colitis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1098330
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098330
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر