Immunohistochemical Studies on Galectin Expression in Colectomised Patients with Ulcerative Colitis
Joint Authors
Block, Mattias
Mölne, Johan
Leffler, Hakon
Börjesson, Lars
Breimer, Michael E.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Introduction.
The aetiology and pathogenesis of ulcerative colitis (UC) are essentially unknown.
Galectins are carbohydrate-binding lectins involved in a large number of physiological and pathophysiological processes.
Little is known about the role of galectins in human UC.
In this immunohistochemical exploratory study, both epithelial and inflammatory cell galectin expression were studied in patients with a thoroughly documented clinical history and were correlated with inflammatory activity.
Material and Methods.
Surgical whole intestinal wall colon specimens from UC patients ( n = 22 ) and controls ( n = 10 ) were studied.
Clinical history, pharmacological treatment, and modified Mayo-score were recorded.
Tissue inflammation was graded, and sections were stained with antibodies recognizing galectin-1, galectin-2, galectin-3, and galectin-4.
Results.
Galectin-1 was undetectable in normal and UC colonic epithelium, while galectin-2, galectin-3, and galectin-4 were strongly expressed.
A tendency towards diminished epithelial expression with increased inflammatory grade for galectin-2, galectin-3, and galectin-4 was also found.
In the inflammatory cells, a strong expression of galectin-2 and a weak expression of galectin-3 were seen.
No clear-cut correlation between epithelial galectin expression and severity of the disease was found.
Conclusion.
Galectin expression in patients with UC seems to be more dependent on disease focality and individual variation than on degree of tissue inflammation.
American Psychological Association (APA)
Block, Mattias& Mölne, Johan& Leffler, Hakon& Börjesson, Lars& Breimer, Michael E.. 2016. Immunohistochemical Studies on Galectin Expression in Colectomised Patients with Ulcerative Colitis. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1098330
Modern Language Association (MLA)
Block, Mattias…[et al.]. Immunohistochemical Studies on Galectin Expression in Colectomised Patients with Ulcerative Colitis. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1098330
American Medical Association (AMA)
Block, Mattias& Mölne, Johan& Leffler, Hakon& Börjesson, Lars& Breimer, Michael E.. Immunohistochemical Studies on Galectin Expression in Colectomised Patients with Ulcerative Colitis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1098330
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098330