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MP Resulting in Autophagic Cell Death of Microglia through Zinc Changes against Spinal Cord Injury
المؤلفون المشاركون
Wang, Guannan
Han, Donghe
Bi, Jing
Wan, Zhanghui
Li, Haihong
Li, Dingding
Li, Chenyuan
Wang, Hongyu
Liu, Zhiyuan
Gao, Wei
Gao, Kai
Yao, Tianchen
Mei, Xifan
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-06
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Methylprednisolone pulse therapy (MPPT), as a public recognized therapy of spinal cord injury (SCI), is doubted recently, and the exact mechanism of MP on SCI is unclear.
This study sought to investigate the exact effect of MP on SCI.
We examined the effect of MP in a model of SCI in vivo and an LPS induced model in vitro.
We found that administration of MP produced an increase in the Basso, Beattie, and Bresnahan scores and motor neurons counts of injured rats.
Besides the number of activated microglia was apparently reduced by MP in vivo, and Beclin-1 dependent autophagic cell death of microglia was induced by MP in LPS induced model.
At the same time, MP increases cellular zinc concentration and level of ZIP8, and TPEN could revert effect of MP on autophagic cell death of microglia.
Finally, we have found that MP could inhibit NF-κβ in LPS induced model.
These results show that the MP could result in autophagic cell death of microglia, which mainly depends on increasing cellular labile zinc, and may be associated with inhibition of NF-κβ, and that MP can produce neuroprotective effect in SCI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Dingding& Wang, Guannan& Han, Donghe& Bi, Jing& Li, Chenyuan& Wang, Hongyu…[et al.]. 2016. MP Resulting in Autophagic Cell Death of Microglia through Zinc Changes against Spinal Cord Injury. BioMed Research International،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1098388
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Dingding…[et al.]. MP Resulting in Autophagic Cell Death of Microglia through Zinc Changes against Spinal Cord Injury. BioMed Research International No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1098388
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Dingding& Wang, Guannan& Han, Donghe& Bi, Jing& Li, Chenyuan& Wang, Hongyu…[et al.]. MP Resulting in Autophagic Cell Death of Microglia through Zinc Changes against Spinal Cord Injury. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1098388
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098388
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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