MP Resulting in Autophagic Cell Death of Microglia through Zinc Changes against Spinal Cord Injury
Joint Authors
Wang, Guannan
Han, Donghe
Bi, Jing
Wan, Zhanghui
Li, Haihong
Li, Dingding
Li, Chenyuan
Wang, Hongyu
Liu, Zhiyuan
Gao, Wei
Gao, Kai
Yao, Tianchen
Mei, Xifan
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-06
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Methylprednisolone pulse therapy (MPPT), as a public recognized therapy of spinal cord injury (SCI), is doubted recently, and the exact mechanism of MP on SCI is unclear.
This study sought to investigate the exact effect of MP on SCI.
We examined the effect of MP in a model of SCI in vivo and an LPS induced model in vitro.
We found that administration of MP produced an increase in the Basso, Beattie, and Bresnahan scores and motor neurons counts of injured rats.
Besides the number of activated microglia was apparently reduced by MP in vivo, and Beclin-1 dependent autophagic cell death of microglia was induced by MP in LPS induced model.
At the same time, MP increases cellular zinc concentration and level of ZIP8, and TPEN could revert effect of MP on autophagic cell death of microglia.
Finally, we have found that MP could inhibit NF-κβ in LPS induced model.
These results show that the MP could result in autophagic cell death of microglia, which mainly depends on increasing cellular labile zinc, and may be associated with inhibition of NF-κβ, and that MP can produce neuroprotective effect in SCI.
American Psychological Association (APA)
Li, Dingding& Wang, Guannan& Han, Donghe& Bi, Jing& Li, Chenyuan& Wang, Hongyu…[et al.]. 2016. MP Resulting in Autophagic Cell Death of Microglia through Zinc Changes against Spinal Cord Injury. BioMed Research International،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1098388
Modern Language Association (MLA)
Li, Dingding…[et al.]. MP Resulting in Autophagic Cell Death of Microglia through Zinc Changes against Spinal Cord Injury. BioMed Research International No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1098388
American Medical Association (AMA)
Li, Dingding& Wang, Guannan& Han, Donghe& Bi, Jing& Li, Chenyuan& Wang, Hongyu…[et al.]. MP Resulting in Autophagic Cell Death of Microglia through Zinc Changes against Spinal Cord Injury. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1098388
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098388