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Aqueous Leaf Extract of Jatropha mollissima (Pohl) Bail Decreases Local Effects Induced by Bothropic Venom
المؤلفون المشاركون
Lopes, Norberto Peporine
Fernandes, Júlia Morais
Zucolotto, Silvana Maria
Félix-Silva, Juliana
Gomes, Jacyra Antunes dos Santos
Geraldo Amaral, Juliano
Tabosa do Egito, Eryvaldo Sócrates
Fernandes-Pedrosa, Matheus de Freitas
Silva-Júnior, Arnóbio Antônio da
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-26
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Snakebites are a serious worldwide public health problem.
In Brazil, about 90% of accidents are attributed to snakes from the Bothrops genus.
The specific treatment consists of antivenom serum therapy, which has some limitations such as inability to neutralize local effects, difficult access in some regions, risk of immunological reactions, and high cost.
Thus, the search for alternative therapies to treat snakebites is relevant.
Jatropha mollissima (Euphorbiaceae) is a medicinal plant popularly used in folk medicine as an antiophidic remedy.
Therefore, this study aims to evaluate the effect of the aqueous leaf extract from J.
mollissima on local effects induced by Bothrops venoms.
High Performance Liquid Chromatography with Diode Array Detection analysis and Mass Spectrometry analysis of aqueous leaf extract confirmed the presence of the flavonoids isoschaftoside, schaftoside, isoorientin, orientin, vitexin, and isovitexin.
This extract, at 50–200 mg/kg doses administered by intraperitoneal route, showed significant inhibitory potential against local effects induced by Bothrops erythromelas and Bothrops jararaca snake venoms.
Local skin hemorrhage, local edema, leukocyte migration, and myotoxicity were significantly inhibited by the extract.
These results demonstrate that J.
mollissima extract possesses inhibitory potential, especially against bothropic venoms, suggesting its potential as an adjuvant in treatment of snakebites.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gomes, Jacyra Antunes dos Santos& Félix-Silva, Juliana& Fernandes, Júlia Morais& Geraldo Amaral, Juliano& Lopes, Norberto Peporine& Tabosa do Egito, Eryvaldo Sócrates…[et al.]. 2016. Aqueous Leaf Extract of Jatropha mollissima (Pohl) Bail Decreases Local Effects Induced by Bothropic Venom. BioMed Research International،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1098392
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gomes, Jacyra Antunes dos Santos…[et al.]. Aqueous Leaf Extract of Jatropha mollissima (Pohl) Bail Decreases Local Effects Induced by Bothropic Venom. BioMed Research International No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1098392
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gomes, Jacyra Antunes dos Santos& Félix-Silva, Juliana& Fernandes, Júlia Morais& Geraldo Amaral, Juliano& Lopes, Norberto Peporine& Tabosa do Egito, Eryvaldo Sócrates…[et al.]. Aqueous Leaf Extract of Jatropha mollissima (Pohl) Bail Decreases Local Effects Induced by Bothropic Venom. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1098392
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098392
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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