WWOX CNV-67048 Functions as a Risk Factor for Epithelial Ovarian Cancer in Chinese Women by Negatively Interacting with Oral Contraceptive Use
المؤلفون المشاركون
Chen, Yongxiu
Tan, Xiaochang
Ding, Yongli
Mai, Bi
Huang, Xiaowen
Hu, Guiying
Luo, Xiping
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-11
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Copy number variations (CNVs) have attracted increasing evidences to represent their roles as cancer susceptibility regulators.
However, little is known about the role of CNV in epithelia ovarian cancer (EOC).
Recently, the CNV-67048 of WW domain-containing oxidoreductase (WWOX) was reported to alter cancer risks.
Considering that WWOX also plays a role in EOC, we hypothesized that the CNV-67048 was associated with EOC risk.
In a case-control study of 549 EOC patients and 571 age (±5 years) matched cancer-free controls, we found that the low copy number of CNV-67048 (1-copy and 0-copy) conferred a significantly increased risk of EOC (OR = 1.346, 95% CI = 1.037–1.747) and it determined the risk by means of copy number-dependent dosage effect ( P = 0.009 ).
Data from TCGA also confirmed the abovementioned association as the frequency of low copies in EOC group was 3.68 times more than that in healthy group ( P = 0.023 ).
The CNV also negatively interacted with oral contraceptive use on EOC risk ( P = 0.042 ).
Functional analyses further showed a lower mRNA level of WWOX in tissues with the 0-copy or 1-copy than that in those with the 2-copy ( P = 0.045 ).
Our data suggested the CNV-67048 to be a risk factor of EOC in Chinese women.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Yongxiu& Tan, Xiaochang& Ding, Yongli& Mai, Bi& Huang, Xiaowen& Hu, Guiying…[et al.]. 2016. WWOX CNV-67048 Functions as a Risk Factor for Epithelial Ovarian Cancer in Chinese Women by Negatively Interacting with Oral Contraceptive Use. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098520
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Yongxiu…[et al.]. WWOX CNV-67048 Functions as a Risk Factor for Epithelial Ovarian Cancer in Chinese Women by Negatively Interacting with Oral Contraceptive Use. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1098520
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Yongxiu& Tan, Xiaochang& Ding, Yongli& Mai, Bi& Huang, Xiaowen& Hu, Guiying…[et al.]. WWOX CNV-67048 Functions as a Risk Factor for Epithelial Ovarian Cancer in Chinese Women by Negatively Interacting with Oral Contraceptive Use. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098520
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098520
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر