WWOX CNV-67048 Functions as a Risk Factor for Epithelial Ovarian Cancer in Chinese Women by Negatively Interacting with Oral Contraceptive Use
Joint Authors
Chen, Yongxiu
Tan, Xiaochang
Ding, Yongli
Mai, Bi
Huang, Xiaowen
Hu, Guiying
Luo, Xiping
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Copy number variations (CNVs) have attracted increasing evidences to represent their roles as cancer susceptibility regulators.
However, little is known about the role of CNV in epithelia ovarian cancer (EOC).
Recently, the CNV-67048 of WW domain-containing oxidoreductase (WWOX) was reported to alter cancer risks.
Considering that WWOX also plays a role in EOC, we hypothesized that the CNV-67048 was associated with EOC risk.
In a case-control study of 549 EOC patients and 571 age (±5 years) matched cancer-free controls, we found that the low copy number of CNV-67048 (1-copy and 0-copy) conferred a significantly increased risk of EOC (OR = 1.346, 95% CI = 1.037–1.747) and it determined the risk by means of copy number-dependent dosage effect ( P = 0.009 ).
Data from TCGA also confirmed the abovementioned association as the frequency of low copies in EOC group was 3.68 times more than that in healthy group ( P = 0.023 ).
The CNV also negatively interacted with oral contraceptive use on EOC risk ( P = 0.042 ).
Functional analyses further showed a lower mRNA level of WWOX in tissues with the 0-copy or 1-copy than that in those with the 2-copy ( P = 0.045 ).
Our data suggested the CNV-67048 to be a risk factor of EOC in Chinese women.
American Psychological Association (APA)
Chen, Yongxiu& Tan, Xiaochang& Ding, Yongli& Mai, Bi& Huang, Xiaowen& Hu, Guiying…[et al.]. 2016. WWOX CNV-67048 Functions as a Risk Factor for Epithelial Ovarian Cancer in Chinese Women by Negatively Interacting with Oral Contraceptive Use. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098520
Modern Language Association (MLA)
Chen, Yongxiu…[et al.]. WWOX CNV-67048 Functions as a Risk Factor for Epithelial Ovarian Cancer in Chinese Women by Negatively Interacting with Oral Contraceptive Use. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1098520
American Medical Association (AMA)
Chen, Yongxiu& Tan, Xiaochang& Ding, Yongli& Mai, Bi& Huang, Xiaowen& Hu, Guiying…[et al.]. WWOX CNV-67048 Functions as a Risk Factor for Epithelial Ovarian Cancer in Chinese Women by Negatively Interacting with Oral Contraceptive Use. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098520
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098520