A Meta-Path-Based Prediction Method for Human miRNA-Target Association

المؤلفون المشاركون

Luo, Jiawei
Huang, Cong
Ding, Pingjian

المصدر

BioMed Research International

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-09-15

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الطب البشري

الملخص EN

MicroRNAs (miRNAs) are short noncoding RNAs that play important roles in regulating gene expressing, and the perturbed miRNAs are often associated with development and tumorigenesis as they have effects on their target mRNA.

Predicting potential miRNA-target associations from multiple types of genomic data is a considerable problem in the bioinformatics research.

However, most of the existing methods did not fully use the experimentally validated miRNA-mRNA interactions.

Here, we developed RMLM and RMLMSe to predict the relationship between miRNAs and their targets.

RMLM and RMLMSe are global approaches as they can reconstruct the missing associations for all the miRNA-target simultaneously and RMLMSe demonstrates that the integration of sequence information can improve the performance of RMLM.

In RMLM, we use RM measure to evaluate different relatedness between miRNA and its target based on different meta-paths; logistic regression and MLE method are employed to estimate the weight of different meta-paths.

In RMLMSe, sequence information is utilized to improve the performance of RMLM.

Here, we carry on fivefold cross validation and pathway enrichment analysis to prove the performance of our methods.

The fivefold experiments show that our methods have higher AUC scores compared with other methods and the integration of sequence information can improve the performance of miRNA-target association prediction.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Luo, Jiawei& Huang, Cong& Ding, Pingjian. 2016. A Meta-Path-Based Prediction Method for Human miRNA-Target Association. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098791

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Luo, Jiawei…[et al.]. A Meta-Path-Based Prediction Method for Human miRNA-Target Association. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1098791

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Luo, Jiawei& Huang, Cong& Ding, Pingjian. A Meta-Path-Based Prediction Method for Human miRNA-Target Association. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098791

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1098791