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A Meta-Path-Based Prediction Method for Human miRNA-Target Association
Joint Authors
Luo, Jiawei
Huang, Cong
Ding, Pingjian
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
MicroRNAs (miRNAs) are short noncoding RNAs that play important roles in regulating gene expressing, and the perturbed miRNAs are often associated with development and tumorigenesis as they have effects on their target mRNA.
Predicting potential miRNA-target associations from multiple types of genomic data is a considerable problem in the bioinformatics research.
However, most of the existing methods did not fully use the experimentally validated miRNA-mRNA interactions.
Here, we developed RMLM and RMLMSe to predict the relationship between miRNAs and their targets.
RMLM and RMLMSe are global approaches as they can reconstruct the missing associations for all the miRNA-target simultaneously and RMLMSe demonstrates that the integration of sequence information can improve the performance of RMLM.
In RMLM, we use RM measure to evaluate different relatedness between miRNA and its target based on different meta-paths; logistic regression and MLE method are employed to estimate the weight of different meta-paths.
In RMLMSe, sequence information is utilized to improve the performance of RMLM.
Here, we carry on fivefold cross validation and pathway enrichment analysis to prove the performance of our methods.
The fivefold experiments show that our methods have higher AUC scores compared with other methods and the integration of sequence information can improve the performance of miRNA-target association prediction.
American Psychological Association (APA)
Luo, Jiawei& Huang, Cong& Ding, Pingjian. 2016. A Meta-Path-Based Prediction Method for Human miRNA-Target Association. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098791
Modern Language Association (MLA)
Luo, Jiawei…[et al.]. A Meta-Path-Based Prediction Method for Human miRNA-Target Association. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1098791
American Medical Association (AMA)
Luo, Jiawei& Huang, Cong& Ding, Pingjian. A Meta-Path-Based Prediction Method for Human miRNA-Target Association. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098791
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098791