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Serum Heme Oxygenase-1 and BMP-7 Are Potential Biomarkers for Bone Metabolism in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis
المؤلفون المشاركون
Wei, James Cheng-Chung
Liu, Yi
Herrmann, Martin
Zhao, Yi
Yuan, Tong-ling
Chen, Jin
Tong, Yan-li
Zhang, Yan
Liu, Yuan-yuan
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-26
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Backgrounds.
Heme oxygenase-1 (HO-1) has been reported to play a regulatory role in osteoclastogenesis.
Bone morphogenetic protein (BMP) pathways induce osteoblastic differentiation and bone remodeling.
Aims.
To identify serum levels of HO-1, BMP-7, and Runt related-transcription factor 2 (Runx2) in patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS) and to investigate the relationships between HO-1, BMP-7, Runx2, and other common biomarkers for bone metabolism.
Results.
Serum levels of HO-1 and BMP-7 were revealed to be significantly higher in patients with RA or AS than in healthy controls (p<0.01).
In RA group, HO-1 was positively correlated with BMP-7, Runx2, and tartrate-resistant acid phosphatase-5b (TRAP-5b) (p<0.05, resp.), BMP-7 was positively correlated with Runx2 and TRAP-5b (p<0.05, resp.), and Runx2 was negatively correlated with N-terminal midfragment of osteocalcin (NMID) (p<0.05).
In AS group, we observed identical correlation between HO-1 and BMP-7, but opposite correlations between BMP-7 and TRAP-5b and between Runx2 and NMID, when comparing with the RA cohort.
Conclusion.
Our findings suggest that HO-1 and BMP-7 are potential biomarkers for bone metabolism in patients with RA and AS.
The different correlations between the bone markers point to distinct differences in bone remodeling pathways in the two types of arthritis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yuan, Tong-ling& Chen, Jin& Tong, Yan-li& Zhang, Yan& Liu, Yuan-yuan& Wei, James Cheng-Chung…[et al.]. 2016. Serum Heme Oxygenase-1 and BMP-7 Are Potential Biomarkers for Bone Metabolism in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098874
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yuan, Tong-ling…[et al.]. Serum Heme Oxygenase-1 and BMP-7 Are Potential Biomarkers for Bone Metabolism in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1098874
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yuan, Tong-ling& Chen, Jin& Tong, Yan-li& Zhang, Yan& Liu, Yuan-yuan& Wei, James Cheng-Chung…[et al.]. Serum Heme Oxygenase-1 and BMP-7 Are Potential Biomarkers for Bone Metabolism in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098874
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098874
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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