Serum Heme Oxygenase-1 and BMP-7 Are Potential Biomarkers for Bone Metabolism in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis
Joint Authors
Wei, James Cheng-Chung
Liu, Yi
Herrmann, Martin
Zhao, Yi
Yuan, Tong-ling
Chen, Jin
Tong, Yan-li
Zhang, Yan
Liu, Yuan-yuan
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Backgrounds.
Heme oxygenase-1 (HO-1) has been reported to play a regulatory role in osteoclastogenesis.
Bone morphogenetic protein (BMP) pathways induce osteoblastic differentiation and bone remodeling.
Aims.
To identify serum levels of HO-1, BMP-7, and Runt related-transcription factor 2 (Runx2) in patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS) and to investigate the relationships between HO-1, BMP-7, Runx2, and other common biomarkers for bone metabolism.
Results.
Serum levels of HO-1 and BMP-7 were revealed to be significantly higher in patients with RA or AS than in healthy controls (p<0.01).
In RA group, HO-1 was positively correlated with BMP-7, Runx2, and tartrate-resistant acid phosphatase-5b (TRAP-5b) (p<0.05, resp.), BMP-7 was positively correlated with Runx2 and TRAP-5b (p<0.05, resp.), and Runx2 was negatively correlated with N-terminal midfragment of osteocalcin (NMID) (p<0.05).
In AS group, we observed identical correlation between HO-1 and BMP-7, but opposite correlations between BMP-7 and TRAP-5b and between Runx2 and NMID, when comparing with the RA cohort.
Conclusion.
Our findings suggest that HO-1 and BMP-7 are potential biomarkers for bone metabolism in patients with RA and AS.
The different correlations between the bone markers point to distinct differences in bone remodeling pathways in the two types of arthritis.
American Psychological Association (APA)
Yuan, Tong-ling& Chen, Jin& Tong, Yan-li& Zhang, Yan& Liu, Yuan-yuan& Wei, James Cheng-Chung…[et al.]. 2016. Serum Heme Oxygenase-1 and BMP-7 Are Potential Biomarkers for Bone Metabolism in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098874
Modern Language Association (MLA)
Yuan, Tong-ling…[et al.]. Serum Heme Oxygenase-1 and BMP-7 Are Potential Biomarkers for Bone Metabolism in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1098874
American Medical Association (AMA)
Yuan, Tong-ling& Chen, Jin& Tong, Yan-li& Zhang, Yan& Liu, Yuan-yuan& Wei, James Cheng-Chung…[et al.]. Serum Heme Oxygenase-1 and BMP-7 Are Potential Biomarkers for Bone Metabolism in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098874
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098874