Assessment of the Number and Phenotype of Macrophages in the Human BMB Samples of CML
المؤلفون المشاركون
Song, Jian-Xin
Dian, Zi-Jin
Wen, Yan
Mei, Fen
Li, Rui-Wei
Sa, Ya-Lian
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-24
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Macrophages have emerged as a key player in tumor biology.
However, their number and phenotype in human bone marrow of biopsy (BMB) samples of chronic myeloid leukemia (CML) and their association with disease progression from an initial chronic phase (CP) to accelerated phase (AP) to advanced blast phase (BP) are still unclear.
BMB samples from 127 CML patients and 30 patients with iron-deficiency anemia (IDA) as control group were analyzed by immunohistochemistry.
The expression levels of CD68, CD163, and CD206 in BMB samples of CML patients were significantly higher than those in the patients of control group ( P < 0.01 ), and we observed that their positive expression was gradually elevated during the transformation of CML-CP to AP to BP ( P < 0.01 ).
However, the expressions of CD68, CD163, and CD206 in released group were downregulated and contrasted to these in control group; there exists statistical significance ( P < 0.01 ).
The percentage ratio of CD163 and CD206 to CD68 was pronounced to be increasing from CML-CP to AP to BP ( P < 0.01 ).
Hence, the higher proportion of CD68+, CD163+ and CD206+ macrophages in BMB samples can be considered a key factor for disease progression of CML patients.
Targeting macrophages, especially the M2 phenotype may help in designing therapeutic strategies for CML.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Song, Jian-Xin& Dian, Zi-Jin& Wen, Yan& Mei, Fen& Li, Rui-Wei& Sa, Ya-Lian. 2016. Assessment of the Number and Phenotype of Macrophages in the Human BMB Samples of CML. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098969
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Song, Jian-Xin…[et al.]. Assessment of the Number and Phenotype of Macrophages in the Human BMB Samples of CML. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1098969
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Song, Jian-Xin& Dian, Zi-Jin& Wen, Yan& Mei, Fen& Li, Rui-Wei& Sa, Ya-Lian. Assessment of the Number and Phenotype of Macrophages in the Human BMB Samples of CML. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098969
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098969
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر