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Assessment of the Number and Phenotype of Macrophages in the Human BMB Samples of CML
Joint Authors
Song, Jian-Xin
Dian, Zi-Jin
Wen, Yan
Mei, Fen
Li, Rui-Wei
Sa, Ya-Lian
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Macrophages have emerged as a key player in tumor biology.
However, their number and phenotype in human bone marrow of biopsy (BMB) samples of chronic myeloid leukemia (CML) and their association with disease progression from an initial chronic phase (CP) to accelerated phase (AP) to advanced blast phase (BP) are still unclear.
BMB samples from 127 CML patients and 30 patients with iron-deficiency anemia (IDA) as control group were analyzed by immunohistochemistry.
The expression levels of CD68, CD163, and CD206 in BMB samples of CML patients were significantly higher than those in the patients of control group ( P < 0.01 ), and we observed that their positive expression was gradually elevated during the transformation of CML-CP to AP to BP ( P < 0.01 ).
However, the expressions of CD68, CD163, and CD206 in released group were downregulated and contrasted to these in control group; there exists statistical significance ( P < 0.01 ).
The percentage ratio of CD163 and CD206 to CD68 was pronounced to be increasing from CML-CP to AP to BP ( P < 0.01 ).
Hence, the higher proportion of CD68+, CD163+ and CD206+ macrophages in BMB samples can be considered a key factor for disease progression of CML patients.
Targeting macrophages, especially the M2 phenotype may help in designing therapeutic strategies for CML.
American Psychological Association (APA)
Song, Jian-Xin& Dian, Zi-Jin& Wen, Yan& Mei, Fen& Li, Rui-Wei& Sa, Ya-Lian. 2016. Assessment of the Number and Phenotype of Macrophages in the Human BMB Samples of CML. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098969
Modern Language Association (MLA)
Song, Jian-Xin…[et al.]. Assessment of the Number and Phenotype of Macrophages in the Human BMB Samples of CML. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1098969
American Medical Association (AMA)
Song, Jian-Xin& Dian, Zi-Jin& Wen, Yan& Mei, Fen& Li, Rui-Wei& Sa, Ya-Lian. Assessment of the Number and Phenotype of Macrophages in the Human BMB Samples of CML. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098969
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098969