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Role of Cilostazol Therapy in Hemodialysis Patients with Asymptomatic Peripheral Arterial Disease: A Retrospective Cohort Study
المؤلفون المشاركون
Lim, Paik Seong
Jeng, Yachung
Wu, Ming Ying
Pai, Mei-Ann
Wu, Tsai-Kun
Chen, Chang Hsu
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-22
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Peripheral arterial disease (PAD) and its relevant complications are more common in hemodialysis (HD) patients, while the evidence regarding antiplatelet therapy in CKD patients is scarce.
We retrospectively analyzed the efficacy of cilostazol on outcomes in HD patients with asymptomatic PAD (aPAD).
Methods.
This cohort study enrolled 217 HD patients (median follow-up time: 5.75 years).
Associations between cilostazol use and the outcomes were evaluated by time-dependent Cox regression analysis.
Results.
During follow-up, 39.5% (47/119) patients used cilostazol for aPAD and 31.8% (69/217) patients died.
Cilostazol users had significantly lower CVD and all-cause mortalities (adjusted HR [95% CI]: 0.11 [0.03, 0.51] and 0.2 [0.08, 0.52]) than nonusers.
Both death risks were nonsignificantly higher in cilostazol users than in HD patients without aPAD.
The unadjusted and adjusted HR [95% CI] of CVD death risk were 0.4 [0.07, 2.12] and 0.14 [0.02, 0.8] for patients with aPAD during follow-up and were 0.74 [0.16, 3.36] and 0.19 [0.04, 0.93] for those with aPAD at initial.
Conclusions.
In HD patients with aPAD, lower CVD and all-cause mortality rates were observed in low-dose cilostazol user.
Further evidences from large-scale prospective study and randomization trial are desired to confirm the effect of cilostazol.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lim, Paik Seong& Jeng, Yachung& Wu, Ming Ying& Pai, Mei-Ann& Wu, Tsai-Kun& Chen, Chang Hsu. 2016. Role of Cilostazol Therapy in Hemodialysis Patients with Asymptomatic Peripheral Arterial Disease: A Retrospective Cohort Study. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099011
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lim, Paik Seong…[et al.]. Role of Cilostazol Therapy in Hemodialysis Patients with Asymptomatic Peripheral Arterial Disease: A Retrospective Cohort Study. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1099011
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lim, Paik Seong& Jeng, Yachung& Wu, Ming Ying& Pai, Mei-Ann& Wu, Tsai-Kun& Chen, Chang Hsu. Role of Cilostazol Therapy in Hemodialysis Patients with Asymptomatic Peripheral Arterial Disease: A Retrospective Cohort Study. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099011
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1099011
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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