Role of Cilostazol Therapy in Hemodialysis Patients with Asymptomatic Peripheral Arterial Disease: A Retrospective Cohort Study
Joint Authors
Lim, Paik Seong
Jeng, Yachung
Wu, Ming Ying
Pai, Mei-Ann
Wu, Tsai-Kun
Chen, Chang Hsu
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Peripheral arterial disease (PAD) and its relevant complications are more common in hemodialysis (HD) patients, while the evidence regarding antiplatelet therapy in CKD patients is scarce.
We retrospectively analyzed the efficacy of cilostazol on outcomes in HD patients with asymptomatic PAD (aPAD).
Methods.
This cohort study enrolled 217 HD patients (median follow-up time: 5.75 years).
Associations between cilostazol use and the outcomes were evaluated by time-dependent Cox regression analysis.
Results.
During follow-up, 39.5% (47/119) patients used cilostazol for aPAD and 31.8% (69/217) patients died.
Cilostazol users had significantly lower CVD and all-cause mortalities (adjusted HR [95% CI]: 0.11 [0.03, 0.51] and 0.2 [0.08, 0.52]) than nonusers.
Both death risks were nonsignificantly higher in cilostazol users than in HD patients without aPAD.
The unadjusted and adjusted HR [95% CI] of CVD death risk were 0.4 [0.07, 2.12] and 0.14 [0.02, 0.8] for patients with aPAD during follow-up and were 0.74 [0.16, 3.36] and 0.19 [0.04, 0.93] for those with aPAD at initial.
Conclusions.
In HD patients with aPAD, lower CVD and all-cause mortality rates were observed in low-dose cilostazol user.
Further evidences from large-scale prospective study and randomization trial are desired to confirm the effect of cilostazol.
American Psychological Association (APA)
Lim, Paik Seong& Jeng, Yachung& Wu, Ming Ying& Pai, Mei-Ann& Wu, Tsai-Kun& Chen, Chang Hsu. 2016. Role of Cilostazol Therapy in Hemodialysis Patients with Asymptomatic Peripheral Arterial Disease: A Retrospective Cohort Study. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099011
Modern Language Association (MLA)
Lim, Paik Seong…[et al.]. Role of Cilostazol Therapy in Hemodialysis Patients with Asymptomatic Peripheral Arterial Disease: A Retrospective Cohort Study. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1099011
American Medical Association (AMA)
Lim, Paik Seong& Jeng, Yachung& Wu, Ming Ying& Pai, Mei-Ann& Wu, Tsai-Kun& Chen, Chang Hsu. Role of Cilostazol Therapy in Hemodialysis Patients with Asymptomatic Peripheral Arterial Disease: A Retrospective Cohort Study. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099011
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099011