Mathematical Based Calculation of Drug Penetration Depth in Solid Tumors

المؤلفون المشاركون

Namazi, Hamidreza
Kulish, Vladimir V.
Nazeri, Sina
Wong, Albert

المصدر

BioMed Research International

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-06-08

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الطب البشري

الملخص EN

Cancer is a class of diseases characterized by out-of-control cells’ growth which affect cells and make them damaged.

Many treatment options for cancer exist.

Chemotherapy as an important treatment option is the use of drugs to treat cancer.

The anticancer drug travels to the tumor and then diffuses in it through capillaries.

The diffusion of drugs in the solid tumor is limited by penetration depth which is different in case of different drugs and cancers.

The computation of this depth is important as it helps physicians to investigate about treatment of infected tissue.

Although many efforts have been made on studying and measuring drug penetration depth, less works have been done on computing this length from a mathematical point of view.

In this paper, first we propose phase lagging model for diffusion of drug in the tumor.

Then, using this model on one side and considering the classic diffusion on the other side, we compute the drug penetration depth in the solid tumor.

This computed value of drug penetration depth is corroborated by comparison with the values measured by experiments.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Namazi, Hamidreza& Kulish, Vladimir V.& Wong, Albert& Nazeri, Sina. 2016. Mathematical Based Calculation of Drug Penetration Depth in Solid Tumors. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099059

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Namazi, Hamidreza…[et al.]. Mathematical Based Calculation of Drug Penetration Depth in Solid Tumors. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1099059

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Namazi, Hamidreza& Kulish, Vladimir V.& Wong, Albert& Nazeri, Sina. Mathematical Based Calculation of Drug Penetration Depth in Solid Tumors. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099059

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1099059