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Mathematical Based Calculation of Drug Penetration Depth in Solid Tumors
Joint Authors
Namazi, Hamidreza
Kulish, Vladimir V.
Nazeri, Sina
Wong, Albert
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cancer is a class of diseases characterized by out-of-control cells’ growth which affect cells and make them damaged.
Many treatment options for cancer exist.
Chemotherapy as an important treatment option is the use of drugs to treat cancer.
The anticancer drug travels to the tumor and then diffuses in it through capillaries.
The diffusion of drugs in the solid tumor is limited by penetration depth which is different in case of different drugs and cancers.
The computation of this depth is important as it helps physicians to investigate about treatment of infected tissue.
Although many efforts have been made on studying and measuring drug penetration depth, less works have been done on computing this length from a mathematical point of view.
In this paper, first we propose phase lagging model for diffusion of drug in the tumor.
Then, using this model on one side and considering the classic diffusion on the other side, we compute the drug penetration depth in the solid tumor.
This computed value of drug penetration depth is corroborated by comparison with the values measured by experiments.
American Psychological Association (APA)
Namazi, Hamidreza& Kulish, Vladimir V.& Wong, Albert& Nazeri, Sina. 2016. Mathematical Based Calculation of Drug Penetration Depth in Solid Tumors. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099059
Modern Language Association (MLA)
Namazi, Hamidreza…[et al.]. Mathematical Based Calculation of Drug Penetration Depth in Solid Tumors. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1099059
American Medical Association (AMA)
Namazi, Hamidreza& Kulish, Vladimir V.& Wong, Albert& Nazeri, Sina. Mathematical Based Calculation of Drug Penetration Depth in Solid Tumors. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099059
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099059