Lack of Platelet-Activating Factor Receptor Attenuates Experimental Food Allergy but Not Its Metabolic Alterations regarding Adipokine Levels
المؤلفون المشاركون
Cara, Denise Carmona
Faria, Ana Maria Caetano
Batista, Nathália Vieira
Perez, Denise Alves
Pinho, Vanessa
Fonseca, Roberta Cristelli
Pereira, Rafaela Vaz Sousa
Lima Alves, Juliana de
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-25
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Platelet-activating factor (PAF) is known to be an important mediator of anaphylaxis.
However, there is a lack of information in the literature about the role of PAF in food allergy.
The aim of this work was to elucidate the participation of PAF during food allergy development and the consequent adipose tissue inflammation along with its alterations.
Our data demonstrated that, both before oral challenge and after 7 days receiving ovalbumin (OVA) diet, OVA-sensitized mice lacking the PAF receptor (PAFR) showed a decreased level of anti-OVA IgE associated with attenuated allergic markers in comparison to wild type (WT) mice.
Moreover, there was less body weight and adipose tissue loss in PAFR-deficient mice.
However, some features of inflamed adipose tissue presented by sensitized PAFR-deficient and WT mice after oral challenge were similar, such as a higher rate of rolling leukocytes in this tissue and lower circulating levels of adipokines (resistin and adiponectin) in comparison to nonsensitized mice.
Therefore, PAF signaling through PAFR is important for the allergic response to OVA but not for the adipokine alterations caused by this inflammatory process.
Our work clarifies some effects of PAF during food allergy along with its role on the metabolic consequences of this inflammatory process.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Batista, Nathália Vieira& Fonseca, Roberta Cristelli& Perez, Denise Alves& Pereira, Rafaela Vaz Sousa& Lima Alves, Juliana de& Pinho, Vanessa…[et al.]. 2016. Lack of Platelet-Activating Factor Receptor Attenuates Experimental Food Allergy but Not Its Metabolic Alterations regarding Adipokine Levels. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099096
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Batista, Nathália Vieira…[et al.]. Lack of Platelet-Activating Factor Receptor Attenuates Experimental Food Allergy but Not Its Metabolic Alterations regarding Adipokine Levels. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1099096
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Batista, Nathália Vieira& Fonseca, Roberta Cristelli& Perez, Denise Alves& Pereira, Rafaela Vaz Sousa& Lima Alves, Juliana de& Pinho, Vanessa…[et al.]. Lack of Platelet-Activating Factor Receptor Attenuates Experimental Food Allergy but Not Its Metabolic Alterations regarding Adipokine Levels. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099096
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1099096
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر