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Lack of Platelet-Activating Factor Receptor Attenuates Experimental Food Allergy but Not Its Metabolic Alterations regarding Adipokine Levels
Joint Authors
Cara, Denise Carmona
Faria, Ana Maria Caetano
Batista, Nathália Vieira
Perez, Denise Alves
Pinho, Vanessa
Fonseca, Roberta Cristelli
Pereira, Rafaela Vaz Sousa
Lima Alves, Juliana de
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Platelet-activating factor (PAF) is known to be an important mediator of anaphylaxis.
However, there is a lack of information in the literature about the role of PAF in food allergy.
The aim of this work was to elucidate the participation of PAF during food allergy development and the consequent adipose tissue inflammation along with its alterations.
Our data demonstrated that, both before oral challenge and after 7 days receiving ovalbumin (OVA) diet, OVA-sensitized mice lacking the PAF receptor (PAFR) showed a decreased level of anti-OVA IgE associated with attenuated allergic markers in comparison to wild type (WT) mice.
Moreover, there was less body weight and adipose tissue loss in PAFR-deficient mice.
However, some features of inflamed adipose tissue presented by sensitized PAFR-deficient and WT mice after oral challenge were similar, such as a higher rate of rolling leukocytes in this tissue and lower circulating levels of adipokines (resistin and adiponectin) in comparison to nonsensitized mice.
Therefore, PAF signaling through PAFR is important for the allergic response to OVA but not for the adipokine alterations caused by this inflammatory process.
Our work clarifies some effects of PAF during food allergy along with its role on the metabolic consequences of this inflammatory process.
American Psychological Association (APA)
Batista, Nathália Vieira& Fonseca, Roberta Cristelli& Perez, Denise Alves& Pereira, Rafaela Vaz Sousa& Lima Alves, Juliana de& Pinho, Vanessa…[et al.]. 2016. Lack of Platelet-Activating Factor Receptor Attenuates Experimental Food Allergy but Not Its Metabolic Alterations regarding Adipokine Levels. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099096
Modern Language Association (MLA)
Batista, Nathália Vieira…[et al.]. Lack of Platelet-Activating Factor Receptor Attenuates Experimental Food Allergy but Not Its Metabolic Alterations regarding Adipokine Levels. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1099096
American Medical Association (AMA)
Batista, Nathália Vieira& Fonseca, Roberta Cristelli& Perez, Denise Alves& Pereira, Rafaela Vaz Sousa& Lima Alves, Juliana de& Pinho, Vanessa…[et al.]. Lack of Platelet-Activating Factor Receptor Attenuates Experimental Food Allergy but Not Its Metabolic Alterations regarding Adipokine Levels. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099096
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099096