Candidate SNP Markers of Chronopathologies Are Predicted by a Significant Change in the Affinity of TATA-Binding Protein for Human Gene Promoters
المؤلفون المشاركون
Ponomarenko, M. P.
Ponomarenko, Mikhail
Rasskazov, Dmitry
Suslov, Valentin
Kolchanov, Nikolay
Sharypova, Ekaterina
Savinkova, Ludmila
Podkolodnaya, Olga
Podkolodny, Nikolay L.
Tverdokhleb, Natalya N.
Chadaeva, Irina
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-21، 21ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-22
دولة النشر
مصر
عدد الصفحات
21
التخصصات الرئيسية
الملخص EN
Variations in human genome (e.g., single nucleotide polymorphisms, SNPs) may be associated with hereditary diseases, their complications, comorbidities, and drug responses.
Using Web service SNP_TATA_Comparator presented in our previous paper, here we analyzed immediate surroundings of known SNP markers of diseases and identified several candidate SNP markers that can significantly change the affinity of TATA-binding protein for human gene promoters, with circadian consequences.
For example, rs572527200 may be related to asthma, where symptoms are circadian (worse at night), and rs367732974 may be associated with heart attacks that are characterized by a circadian preference (early morning).
By the same method, we analyzed the 90 bp proximal promoter region of each protein-coding transcript of each human gene of the circadian clock core.
This analysis yielded 53 candidate SNP markers, such as rs181985043 (susceptibility to acute Q fever in male patients), rs192518038 (higher risk of a heart attack in patients with diabetes), and rs374778785 (emphysema and lung cancer in smokers).
If they are properly validated according to clinical standards, these candidate SNP markers may turn out to be useful for physicians (to select optimal treatment for each patient) and for the general population (to choose a lifestyle preventing possible circadian complications of diseases).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ponomarenko, M. P.& Rasskazov, Dmitry& Suslov, Valentin& Sharypova, Ekaterina& Savinkova, Ludmila& Podkolodnaya, Olga…[et al.]. 2016. Candidate SNP Markers of Chronopathologies Are Predicted by a Significant Change in the Affinity of TATA-Binding Protein for Human Gene Promoters. BioMed Research International،Vol. 2016, no. 2016, pp.1-21.
https://search.emarefa.net/detail/BIM-1099107
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ponomarenko, M. P.…[et al.]. Candidate SNP Markers of Chronopathologies Are Predicted by a Significant Change in the Affinity of TATA-Binding Protein for Human Gene Promoters. BioMed Research International No. 2016 (2016), pp.1-21.
https://search.emarefa.net/detail/BIM-1099107
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ponomarenko, M. P.& Rasskazov, Dmitry& Suslov, Valentin& Sharypova, Ekaterina& Savinkova, Ludmila& Podkolodnaya, Olga…[et al.]. Candidate SNP Markers of Chronopathologies Are Predicted by a Significant Change in the Affinity of TATA-Binding Protein for Human Gene Promoters. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-21.
https://search.emarefa.net/detail/BIM-1099107
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1099107
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر