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Candidate SNP Markers of Chronopathologies Are Predicted by a Significant Change in the Affinity of TATA-Binding Protein for Human Gene Promoters
Joint Authors
Ponomarenko, M. P.
Ponomarenko, Mikhail
Rasskazov, Dmitry
Suslov, Valentin
Kolchanov, Nikolay
Sharypova, Ekaterina
Savinkova, Ludmila
Podkolodnaya, Olga
Podkolodny, Nikolay L.
Tverdokhleb, Natalya N.
Chadaeva, Irina
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-22
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Variations in human genome (e.g., single nucleotide polymorphisms, SNPs) may be associated with hereditary diseases, their complications, comorbidities, and drug responses.
Using Web service SNP_TATA_Comparator presented in our previous paper, here we analyzed immediate surroundings of known SNP markers of diseases and identified several candidate SNP markers that can significantly change the affinity of TATA-binding protein for human gene promoters, with circadian consequences.
For example, rs572527200 may be related to asthma, where symptoms are circadian (worse at night), and rs367732974 may be associated with heart attacks that are characterized by a circadian preference (early morning).
By the same method, we analyzed the 90 bp proximal promoter region of each protein-coding transcript of each human gene of the circadian clock core.
This analysis yielded 53 candidate SNP markers, such as rs181985043 (susceptibility to acute Q fever in male patients), rs192518038 (higher risk of a heart attack in patients with diabetes), and rs374778785 (emphysema and lung cancer in smokers).
If they are properly validated according to clinical standards, these candidate SNP markers may turn out to be useful for physicians (to select optimal treatment for each patient) and for the general population (to choose a lifestyle preventing possible circadian complications of diseases).
American Psychological Association (APA)
Ponomarenko, M. P.& Rasskazov, Dmitry& Suslov, Valentin& Sharypova, Ekaterina& Savinkova, Ludmila& Podkolodnaya, Olga…[et al.]. 2016. Candidate SNP Markers of Chronopathologies Are Predicted by a Significant Change in the Affinity of TATA-Binding Protein for Human Gene Promoters. BioMed Research International،Vol. 2016, no. 2016, pp.1-21.
https://search.emarefa.net/detail/BIM-1099107
Modern Language Association (MLA)
Ponomarenko, M. P.…[et al.]. Candidate SNP Markers of Chronopathologies Are Predicted by a Significant Change in the Affinity of TATA-Binding Protein for Human Gene Promoters. BioMed Research International No. 2016 (2016), pp.1-21.
https://search.emarefa.net/detail/BIM-1099107
American Medical Association (AMA)
Ponomarenko, M. P.& Rasskazov, Dmitry& Suslov, Valentin& Sharypova, Ekaterina& Savinkova, Ludmila& Podkolodnaya, Olga…[et al.]. Candidate SNP Markers of Chronopathologies Are Predicted by a Significant Change in the Affinity of TATA-Binding Protein for Human Gene Promoters. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-21.
https://search.emarefa.net/detail/BIM-1099107
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099107