The Compound of Mangiferin-Berberine Salt Has Potent Activities in Modulating Lipid and Glucose Metabolisms in HepG2 Cells
المؤلفون المشاركون
Kong, Wei-Jia
Wang, Can
Jiang, Jian-Dong
Wu, Wei
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-30
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
The mangiferin-berberine (MB) salt was synthesized by ionic bonding of mangiferin (M) and berberine (B) at an equal molecular ratio.
This study aimed to investigate the activities of MB salt in modulating lipid and glucose metabolisms in HepG2 cells.
After 24 h treatment of the studying compounds, cellular AMP-activated protein kinase α (AMPKα)/acetyl-CoA carboxylase (ACC) protein levels and carnitine palmitoyltransferase (CPT) 1 activities, intracellular lipid contents, mRNA expression levels of target genes, glucose consumption, and glucose production amounts were determined.
Compound C (CC) was used in the blocking experiments.
Our results showed that MB salt increased p-AMPKα (Thr172)/p-ACC (Ser79) levels and CPT1 activity and suppressed oleic acid- (OA-) induced lipid accumulation and upregulation of lipogenic genes potently in HepG2 cells.
The above activities of MB salt were AMPK dependent and were superior to those of M or B when administered at an equal molar concentration.
MB salt enhanced basal and insulin-stimulated glucose consumption and suppressed gluconeogenesis more potently than M or B alone.
The inhibiting activity of MB salt on cellular gluconeogenesis was AMPK dependent.
Our results may support MB salt as a new kind of agent for the development of novel lipid or glucose-lowering drugs in the future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Can& Jiang, Jian-Dong& Wu, Wei& Kong, Wei-Jia. 2016. The Compound of Mangiferin-Berberine Salt Has Potent Activities in Modulating Lipid and Glucose Metabolisms in HepG2 Cells. BioMed Research International،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1099134
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Can…[et al.]. The Compound of Mangiferin-Berberine Salt Has Potent Activities in Modulating Lipid and Glucose Metabolisms in HepG2 Cells. BioMed Research International No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1099134
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Can& Jiang, Jian-Dong& Wu, Wei& Kong, Wei-Jia. The Compound of Mangiferin-Berberine Salt Has Potent Activities in Modulating Lipid and Glucose Metabolisms in HepG2 Cells. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1099134
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1099134
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر