A First Insight into the Genetic Diversity and Drug Susceptibility Pattern of Mycobacterium tuberculosis Complex in Zhejiang, China
المؤلفون المشاركون
Pang, Yu
Liu, Zhengwei
Chen, Songhua
Wu, Beibei
He, Haibo
Pan, Aizhen
Wang, Xiaomeng
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-22
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
In this study, our aim was to determine the predominant genotypes among the Mycobacterium tuberculosis (MTB) strains circulating in Zhejiang Province.
In addition, we also sought to determine the potential associations between MTB genotypes and susceptibility to first-line drugs.
Out of these isolates, 673 (71.6%) were classified into the Beijing genotype, while the other 267 (28.4%) were from non-Beijing families.
The highest proportion of Beijing genotype was found in Huzhou (80.0%) and the lowest in Lishui (48.3%).
Statistical analysis revealed that there was a significant difference in the prevalence of Beijing genotype among different regions (χ2 = 17.57, P = 0.04).
In addition, the overall proportions of drug resistance to INH, RIF, SM, and EMB were 13.2% (124/940), 21.8% (75/940), 3.4% (32/940), and 5.9% (55/940) in Zhejiang, respectively.
Further comparison revealed that there was no significant difference in drug susceptibility profiles between Beijing and non-Beijing strains (P > 0.05).
In conclusion, we describe the genetic diversity and drug susceptibility pattern of MTB in Zhejiang for the first time.
Our data demonstrate that Beijing genotype is the predominant lineage in Zhejiang, while the distribution of Beijing-genotype strains shows geographic diversity.
In addition, no correlation is observed between Beijing genotype and anti-TB drug resistance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Zhengwei& Pang, Yu& Chen, Songhua& Wu, Beibei& He, Haibo& Pan, Aizhen…[et al.]. 2016. A First Insight into the Genetic Diversity and Drug Susceptibility Pattern of Mycobacterium tuberculosis Complex in Zhejiang, China. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099186
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Zhengwei…[et al.]. A First Insight into the Genetic Diversity and Drug Susceptibility Pattern of Mycobacterium tuberculosis Complex in Zhejiang, China. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1099186
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Zhengwei& Pang, Yu& Chen, Songhua& Wu, Beibei& He, Haibo& Pan, Aizhen…[et al.]. A First Insight into the Genetic Diversity and Drug Susceptibility Pattern of Mycobacterium tuberculosis Complex in Zhejiang, China. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099186
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1099186
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر