A First Insight into the Genetic Diversity and Drug Susceptibility Pattern of Mycobacterium tuberculosis Complex in Zhejiang, China
Joint Authors
Pang, Yu
Liu, Zhengwei
Chen, Songhua
Wu, Beibei
He, Haibo
Pan, Aizhen
Wang, Xiaomeng
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In this study, our aim was to determine the predominant genotypes among the Mycobacterium tuberculosis (MTB) strains circulating in Zhejiang Province.
In addition, we also sought to determine the potential associations between MTB genotypes and susceptibility to first-line drugs.
Out of these isolates, 673 (71.6%) were classified into the Beijing genotype, while the other 267 (28.4%) were from non-Beijing families.
The highest proportion of Beijing genotype was found in Huzhou (80.0%) and the lowest in Lishui (48.3%).
Statistical analysis revealed that there was a significant difference in the prevalence of Beijing genotype among different regions (χ2 = 17.57, P = 0.04).
In addition, the overall proportions of drug resistance to INH, RIF, SM, and EMB were 13.2% (124/940), 21.8% (75/940), 3.4% (32/940), and 5.9% (55/940) in Zhejiang, respectively.
Further comparison revealed that there was no significant difference in drug susceptibility profiles between Beijing and non-Beijing strains (P > 0.05).
In conclusion, we describe the genetic diversity and drug susceptibility pattern of MTB in Zhejiang for the first time.
Our data demonstrate that Beijing genotype is the predominant lineage in Zhejiang, while the distribution of Beijing-genotype strains shows geographic diversity.
In addition, no correlation is observed between Beijing genotype and anti-TB drug resistance.
American Psychological Association (APA)
Liu, Zhengwei& Pang, Yu& Chen, Songhua& Wu, Beibei& He, Haibo& Pan, Aizhen…[et al.]. 2016. A First Insight into the Genetic Diversity and Drug Susceptibility Pattern of Mycobacterium tuberculosis Complex in Zhejiang, China. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099186
Modern Language Association (MLA)
Liu, Zhengwei…[et al.]. A First Insight into the Genetic Diversity and Drug Susceptibility Pattern of Mycobacterium tuberculosis Complex in Zhejiang, China. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1099186
American Medical Association (AMA)
Liu, Zhengwei& Pang, Yu& Chen, Songhua& Wu, Beibei& He, Haibo& Pan, Aizhen…[et al.]. A First Insight into the Genetic Diversity and Drug Susceptibility Pattern of Mycobacterium tuberculosis Complex in Zhejiang, China. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099186
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099186