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Functional Roles of NOD1 in Odontoblasts on Dental Pulp Innate Immunity
المؤلفون المشاركون
Takegawa, Daisuke
Yumoto, Hiromichi
Matsuo, Takashi
Hosokawa, Yuki
Hirao, Kouji
Nakanishi, Tadashi
Kitamura, Chiaki
Washio, Ayako
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-25
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Caries-related pathogens are first recognized by odontoblasts and induce inflammatory events that develop to pulpitis.
Generally, initial sensing of microbial pathogens is mediated by pattern recognition receptors, such as Toll-like receptor and nucleotide-binding oligomerization domain (NOD); however, little is known about NODs in odontoblasts.
In this study, the levels of NODs expressed in rat odontoblastic cell line, KN-3, were assessed by flow cytometry and the levels of chemokines in NOD-specific ligand-stimulated KN-3 cells were analyzed by real-time PCR and ELISA.
The signal transduction pathway activated with NOD-specific ligand was assessed by blocking assay with specific inhibitors and reporter assay.
In KN-3 cells, the expression level of NOD1 was stronger than that of NOD2 and the production of chemokines, such as CINC-1, CINC-2, CCL20, and MCP-1, was upregulated by stimulation with NOD1-specific ligand, but not with NOD2-specific ligand.
CINC-2 and CCL20 production by stimulation with NOD1-specific ligand was reduced by p38 MAPK and AP-1 signaling inhibitors.
Furthermore, the reporter assay demonstrated AP-1 activation in NOD1-specific ligand-stimulated KN-3 cells.
These findings indicated that NOD1 expressed in odontoblasts functions to upregulate the chemokines expression via p38-AP-1 signaling pathway and suggested that NOD1 may play important roles in the initiation and progression of pulpitis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hosokawa, Yuki& Hirao, Kouji& Yumoto, Hiromichi& Washio, Ayako& Nakanishi, Tadashi& Takegawa, Daisuke…[et al.]. 2016. Functional Roles of NOD1 in Odontoblasts on Dental Pulp Innate Immunity. BioMed Research International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1099279
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hosokawa, Yuki…[et al.]. Functional Roles of NOD1 in Odontoblasts on Dental Pulp Innate Immunity. BioMed Research International No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1099279
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hosokawa, Yuki& Hirao, Kouji& Yumoto, Hiromichi& Washio, Ayako& Nakanishi, Tadashi& Takegawa, Daisuke…[et al.]. Functional Roles of NOD1 in Odontoblasts on Dental Pulp Innate Immunity. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1099279
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1099279
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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