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Quiescent and Active Tear Protein Profiles to Predict Vernal Keratoconjunctivitis Reactivation
المؤلفون المشاركون
Micera, Alessandra
Calder, Virginia L.
Di Zazzo, Antonio
Sgrulletta, Roberto
Bonini, Stefano
Esposito, Graziana
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-17
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective.
Vernal keratoconjunctivitis (VKC) is a chronic recurrent bilateral inflammation of the conjunctiva associated with atopy.
Several inflammatory and tissue remodeling factors contribute to VKC disease.
The aim is to provide a chip-based protein analysis in tears from patients suffering from quiescent or active VKC.
Methods.
This study cohort included 16 consecutive patients with VKC and 10 controls.
Participants were subjected to clinical assessment of ocular surface and tear sampling.
Total protein quantification, total protein sketch, and protein array (sixty protein candidates) were evaluated.
Results.
An overall increased Fluorescent Intensity expression was observed in VKC arrays.
Particularly, IL1β, IL15, IL21, Eotaxin2, TACE, MIP1α, MIP3α, NCAM1, ICAM2, βNGF, NT4, BDNF, βFGF, SCF, MMP1, and MMP2 were increased in quiescent VKC.
Of those candidates, only IL1β, IL15, IL21, βNGF, SCF, MMP2, Eotaxin2, TACE, MIP1α, MIP3α, NCAM1, and ICAM2 were increased in both active and quiescent VKC.
Finally, NT4, βFGF, and MMP1 were highly increased in active VKC.
Conclusion.
A distinct “protein tear-print” characterizes VKC activity, confirming some previously reported factors and highlighting some new candidates common to quiescent and active states.
Those candidates expressed in quiescent VKC might be considered as predictive indicators of VKC reactivation and/or exacerbation out-of-season.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Micera, Alessandra& Di Zazzo, Antonio& Esposito, Graziana& Sgrulletta, Roberto& Calder, Virginia L.& Bonini, Stefano. 2016. Quiescent and Active Tear Protein Profiles to Predict Vernal Keratoconjunctivitis Reactivation. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099342
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Micera, Alessandra…[et al.]. Quiescent and Active Tear Protein Profiles to Predict Vernal Keratoconjunctivitis Reactivation. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1099342
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Micera, Alessandra& Di Zazzo, Antonio& Esposito, Graziana& Sgrulletta, Roberto& Calder, Virginia L.& Bonini, Stefano. Quiescent and Active Tear Protein Profiles to Predict Vernal Keratoconjunctivitis Reactivation. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099342
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1099342
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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