Angiogenic Effects of CollagenMesoporous Nanoparticle Composite Scaffold Delivering VEGF165

المؤلفون المشاركون

Kim, Joong-Hyun
Kim, Tae-Hyun
Kang, Min Sil
Kim, Hae-Won

المصدر

BioMed Research International

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-09-05

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الطب البشري

الملخص EN

Vascularization is a key issue for the success of tissue engineering to repair damaged tissue.

In this study, we report a composite scaffold delivering angiogenic factor for this purpose.

Vascular endothelial growth factor (VEGF) was loaded on mesoporous silica nanoparticle (MSN), which was then incorporated within a type I collagen sponge, to produce collagen/MSN/VEGF (CMV) scaffold.

The CMV composite scaffold could release VEGF sustainably over the test period of 28 days.

The release of VEGF improved the cell proliferation.

Moreover, the in vivo angiogenesis of the scaffold, as studied by the chick chorioallantoic membrane (CAM) model, showed that the VEGF-releasing scaffold induced significantly increased number of blood vessel complexes when compared with VEGF-free scaffold.

The composite scaffold showed good biocompatibility, as examined in rat subcutaneous tissue.

These results demonstrate that the CMV scaffold with VEGF-releasing capacity can be potentially used to stimulate angiogenesis and tissue repair.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Kim, Joong-Hyun& Kim, Tae-Hyun& Kang, Min Sil& Kim, Hae-Won. 2016. Angiogenic Effects of CollagenMesoporous Nanoparticle Composite Scaffold Delivering VEGF165. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099344

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Kim, Joong-Hyun…[et al.]. Angiogenic Effects of CollagenMesoporous Nanoparticle Composite Scaffold Delivering VEGF165. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1099344

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Kim, Joong-Hyun& Kim, Tae-Hyun& Kang, Min Sil& Kim, Hae-Won. Angiogenic Effects of CollagenMesoporous Nanoparticle Composite Scaffold Delivering VEGF165. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099344

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1099344