Angiogenic Effects of CollagenMesoporous Nanoparticle Composite Scaffold Delivering VEGF165
Joint Authors
Kim, Joong-Hyun
Kim, Tae-Hyun
Kang, Min Sil
Kim, Hae-Won
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Vascularization is a key issue for the success of tissue engineering to repair damaged tissue.
In this study, we report a composite scaffold delivering angiogenic factor for this purpose.
Vascular endothelial growth factor (VEGF) was loaded on mesoporous silica nanoparticle (MSN), which was then incorporated within a type I collagen sponge, to produce collagen/MSN/VEGF (CMV) scaffold.
The CMV composite scaffold could release VEGF sustainably over the test period of 28 days.
The release of VEGF improved the cell proliferation.
Moreover, the in vivo angiogenesis of the scaffold, as studied by the chick chorioallantoic membrane (CAM) model, showed that the VEGF-releasing scaffold induced significantly increased number of blood vessel complexes when compared with VEGF-free scaffold.
The composite scaffold showed good biocompatibility, as examined in rat subcutaneous tissue.
These results demonstrate that the CMV scaffold with VEGF-releasing capacity can be potentially used to stimulate angiogenesis and tissue repair.
American Psychological Association (APA)
Kim, Joong-Hyun& Kim, Tae-Hyun& Kang, Min Sil& Kim, Hae-Won. 2016. Angiogenic Effects of CollagenMesoporous Nanoparticle Composite Scaffold Delivering VEGF165. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099344
Modern Language Association (MLA)
Kim, Joong-Hyun…[et al.]. Angiogenic Effects of CollagenMesoporous Nanoparticle Composite Scaffold Delivering VEGF165. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1099344
American Medical Association (AMA)
Kim, Joong-Hyun& Kim, Tae-Hyun& Kang, Min Sil& Kim, Hae-Won. Angiogenic Effects of CollagenMesoporous Nanoparticle Composite Scaffold Delivering VEGF165. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099344
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099344