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Comparison of Three Chemotherapy Regimens in Elderly Patients with Diffuse Large B Cell Lymphoma: Experience at a Single National Reference Center in Mexico
المؤلفون المشاركون
Nolasco-Medina, Diana
Reynoso-Noveron, Nancy
Aviles-Salas, Alejandro
García-Perez, Osvaldo
Candelaria, Myrna
Mohar, Alejandro
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-10
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Although chemotherapy added to rituximab is a standard of care for diffuse large B cell lymphoma (DLBCL), treatment of patients ≥65 years of age remains controversial due to comorbidities.
Methods.
This is a retrospective, comparative, nonrandomized study of patients ≥65 years of age, who were diagnosed with DLBCL but not previously treated.
Demographic characteristics and comorbidities were analyzed.
Three rituximab-containing treatment regimens (standard RCHOP, anthracycline dose-reduced RChOP, and RCOP) were compared.
Descriptive analyses were conducted.
Survival was calculated with the Kaplan-Meier method, and differences were compared with the log-rank test.
Results.
In total, 141 patients with a median age of 73.9 years were studied.
The three treatment groups had comparable demographic characteristics.
The overall response was 77%, 72.5%, and 59% in groups treated with RCHOP, RChOP, and RCOP, respectively.
After multivariate analysis, the factors influencing the overall survival were the presence of B symptoms, poor performance status (ECOG ≥ 3), and febrile neutropenia.
Factors influencing disease-free survival were febrile neutropenia, high-intermediate and high-risk IPI scores, and treatment without anthracycline.
Conclusion.
A higher ORR (overall response rate) was achieved with standard RCHOP, which influenced DFS and OS, although it was not statistically significant compared with the other groups.
Interventional phase 3 trials testing new molecules in patients aged 70 to 80 years and older are required to improve the prognosis within this growing population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nolasco-Medina, Diana& Reynoso-Noveron, Nancy& Mohar, Alejandro& Aviles-Salas, Alejandro& García-Perez, Osvaldo& Candelaria, Myrna. 2016. Comparison of Three Chemotherapy Regimens in Elderly Patients with Diffuse Large B Cell Lymphoma: Experience at a Single National Reference Center in Mexico. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099402
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nolasco-Medina, Diana…[et al.]. Comparison of Three Chemotherapy Regimens in Elderly Patients with Diffuse Large B Cell Lymphoma: Experience at a Single National Reference Center in Mexico. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1099402
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nolasco-Medina, Diana& Reynoso-Noveron, Nancy& Mohar, Alejandro& Aviles-Salas, Alejandro& García-Perez, Osvaldo& Candelaria, Myrna. Comparison of Three Chemotherapy Regimens in Elderly Patients with Diffuse Large B Cell Lymphoma: Experience at a Single National Reference Center in Mexico. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099402
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1099402
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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