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Comparison of Three Chemotherapy Regimens in Elderly Patients with Diffuse Large B Cell Lymphoma: Experience at a Single National Reference Center in Mexico
Joint Authors
Nolasco-Medina, Diana
Reynoso-Noveron, Nancy
Aviles-Salas, Alejandro
García-Perez, Osvaldo
Candelaria, Myrna
Mohar, Alejandro
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Although chemotherapy added to rituximab is a standard of care for diffuse large B cell lymphoma (DLBCL), treatment of patients ≥65 years of age remains controversial due to comorbidities.
Methods.
This is a retrospective, comparative, nonrandomized study of patients ≥65 years of age, who were diagnosed with DLBCL but not previously treated.
Demographic characteristics and comorbidities were analyzed.
Three rituximab-containing treatment regimens (standard RCHOP, anthracycline dose-reduced RChOP, and RCOP) were compared.
Descriptive analyses were conducted.
Survival was calculated with the Kaplan-Meier method, and differences were compared with the log-rank test.
Results.
In total, 141 patients with a median age of 73.9 years were studied.
The three treatment groups had comparable demographic characteristics.
The overall response was 77%, 72.5%, and 59% in groups treated with RCHOP, RChOP, and RCOP, respectively.
After multivariate analysis, the factors influencing the overall survival were the presence of B symptoms, poor performance status (ECOG ≥ 3), and febrile neutropenia.
Factors influencing disease-free survival were febrile neutropenia, high-intermediate and high-risk IPI scores, and treatment without anthracycline.
Conclusion.
A higher ORR (overall response rate) was achieved with standard RCHOP, which influenced DFS and OS, although it was not statistically significant compared with the other groups.
Interventional phase 3 trials testing new molecules in patients aged 70 to 80 years and older are required to improve the prognosis within this growing population.
American Psychological Association (APA)
Nolasco-Medina, Diana& Reynoso-Noveron, Nancy& Mohar, Alejandro& Aviles-Salas, Alejandro& García-Perez, Osvaldo& Candelaria, Myrna. 2016. Comparison of Three Chemotherapy Regimens in Elderly Patients with Diffuse Large B Cell Lymphoma: Experience at a Single National Reference Center in Mexico. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099402
Modern Language Association (MLA)
Nolasco-Medina, Diana…[et al.]. Comparison of Three Chemotherapy Regimens in Elderly Patients with Diffuse Large B Cell Lymphoma: Experience at a Single National Reference Center in Mexico. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1099402
American Medical Association (AMA)
Nolasco-Medina, Diana& Reynoso-Noveron, Nancy& Mohar, Alejandro& Aviles-Salas, Alejandro& García-Perez, Osvaldo& Candelaria, Myrna. Comparison of Three Chemotherapy Regimens in Elderly Patients with Diffuse Large B Cell Lymphoma: Experience at a Single National Reference Center in Mexico. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099402
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099402