The Effect of Task-Irrelevant Fearful-Face Distractor on Working Memory Processing in Mild Cognitive Impairment versus Healthy Controls: An Exploratory fMRI Study in Female Participants
المؤلفون المشاركون
Burhan, Amer
Anazodo, Udunna C.
Chung, Jun Ku
Arena, Amanda
Graff-Guerrero, Ariel
Mitchell, Derek G. V.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-01
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
In mild cognitive impairment (MCI), a risk state for Alzheimer’s disease, patients have objective cognitive deficits with relatively preserved functioning.
fMRI studies have identified anomalies during working memory (WM) processing in individuals with MCI.
The effect of task-irrelevant emotional face distractor on WM processing in MCI remains unclear.
We aim to explore the impact of fearful-face task-irrelevant distractor on WM processing in MCI using fMRI.
Hypothesis.
Compared to healthy controls (HC), MCI patients will show significantly higher BOLD signal in a priori identified regions of interest (ROIs) during a WM task with a task-irrelevant emotional face distractor.
Methods.
9 right-handed female participants with MCI and 12 matched HC performed a WM task with standardized task-irrelevant fearful versus neutral face distractors randomized and counterbalanced across WM trials.
MRI images were acquired during the WM task and BOLD signal was analyzed using statistical parametric mapping (SPM) to identify signal patterns during the task response phase.
Results.
Task-irrelevant fearful-face distractor resulted in higher activation in the amygdala, anterior cingulate, and frontal areas, in MCI participants compared to HC.
Conclusions.
This exploratory study suggests altered WM processing as a result of fearful-face distractor in MCI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Burhan, Amer& Anazodo, Udunna C.& Chung, Jun Ku& Arena, Amanda& Graff-Guerrero, Ariel& Mitchell, Derek G. V.. 2016. The Effect of Task-Irrelevant Fearful-Face Distractor on Working Memory Processing in Mild Cognitive Impairment versus Healthy Controls: An Exploratory fMRI Study in Female Participants. Behavioural Neurology،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1099430
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Burhan, Amer…[et al.]. The Effect of Task-Irrelevant Fearful-Face Distractor on Working Memory Processing in Mild Cognitive Impairment versus Healthy Controls: An Exploratory fMRI Study in Female Participants. Behavioural Neurology No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1099430
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Burhan, Amer& Anazodo, Udunna C.& Chung, Jun Ku& Arena, Amanda& Graff-Guerrero, Ariel& Mitchell, Derek G. V.. The Effect of Task-Irrelevant Fearful-Face Distractor on Working Memory Processing in Mild Cognitive Impairment versus Healthy Controls: An Exploratory fMRI Study in Female Participants. Behavioural Neurology. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1099430
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1099430
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر