The Effect of Task-Irrelevant Fearful-Face Distractor on Working Memory Processing in Mild Cognitive Impairment versus Healthy Controls: An Exploratory fMRI Study in Female Participants
Joint Authors
Burhan, Amer
Anazodo, Udunna C.
Chung, Jun Ku
Arena, Amanda
Graff-Guerrero, Ariel
Mitchell, Derek G. V.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-01
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
In mild cognitive impairment (MCI), a risk state for Alzheimer’s disease, patients have objective cognitive deficits with relatively preserved functioning.
fMRI studies have identified anomalies during working memory (WM) processing in individuals with MCI.
The effect of task-irrelevant emotional face distractor on WM processing in MCI remains unclear.
We aim to explore the impact of fearful-face task-irrelevant distractor on WM processing in MCI using fMRI.
Hypothesis.
Compared to healthy controls (HC), MCI patients will show significantly higher BOLD signal in a priori identified regions of interest (ROIs) during a WM task with a task-irrelevant emotional face distractor.
Methods.
9 right-handed female participants with MCI and 12 matched HC performed a WM task with standardized task-irrelevant fearful versus neutral face distractors randomized and counterbalanced across WM trials.
MRI images were acquired during the WM task and BOLD signal was analyzed using statistical parametric mapping (SPM) to identify signal patterns during the task response phase.
Results.
Task-irrelevant fearful-face distractor resulted in higher activation in the amygdala, anterior cingulate, and frontal areas, in MCI participants compared to HC.
Conclusions.
This exploratory study suggests altered WM processing as a result of fearful-face distractor in MCI.
American Psychological Association (APA)
Burhan, Amer& Anazodo, Udunna C.& Chung, Jun Ku& Arena, Amanda& Graff-Guerrero, Ariel& Mitchell, Derek G. V.. 2016. The Effect of Task-Irrelevant Fearful-Face Distractor on Working Memory Processing in Mild Cognitive Impairment versus Healthy Controls: An Exploratory fMRI Study in Female Participants. Behavioural Neurology،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1099430
Modern Language Association (MLA)
Burhan, Amer…[et al.]. The Effect of Task-Irrelevant Fearful-Face Distractor on Working Memory Processing in Mild Cognitive Impairment versus Healthy Controls: An Exploratory fMRI Study in Female Participants. Behavioural Neurology No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1099430
American Medical Association (AMA)
Burhan, Amer& Anazodo, Udunna C.& Chung, Jun Ku& Arena, Amanda& Graff-Guerrero, Ariel& Mitchell, Derek G. V.. The Effect of Task-Irrelevant Fearful-Face Distractor on Working Memory Processing in Mild Cognitive Impairment versus Healthy Controls: An Exploratory fMRI Study in Female Participants. Behavioural Neurology. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1099430
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099430