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Achievement of Vancomycin Therapeutic Goals in Critically Ill Patients: Early Individualization May Be Beneficial
المؤلفون المشاركون
Mousavi, Sarah
Shahrami, Bita
Najmeddin, Farhad
Ahmadi, Arezoo
Rouini, Mohammad Reza
Sadeghi, Kourosh
Mojtahedzadeh, Mojtaba
المصدر
Critical Care Research and Practice
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-17
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
The aim of our study was to assess and validate the effectiveness of early dose adjustment of vancomycin based on first dose monitoring in achieving target recommended goal in critically ill patients.
Methods.
Twenty critically ill patients with sepsis received loading dose of 25 mg/kg of vancomycin and then were randomly assigned to 2 groups.
Group 1 received maximum empirical doses of vancomycin of 15 mg/kg every 8 hrs.
In group 2, the doses were individualized based on serum concentrations of vancomycin.
First dose nonsteady state sampling was used to calculate pharmacokinetic parameters of the patients within 24 hours.
Results.
Steady state trough serum concentrations were significantly higher in group 2 in comparison with group 1 (19.4 ± 4.4 mg/L versus 14.4 ± 4.3 mg/L) (P=0.03).
Steady state AUCs were significantly higher in group 2 compared with group 1 (665.9 ± 136.5 mg·hr/L versus 490.7 ± 101.1 mg·hr/L) (P=0.008).
Conclusions.
With early individualized dosing regimen, significantly more patients achieved peak and trough steady state concentrations.
In the context of pharmacokinetic/pharmacodynamic goal of area under the time concentration curve to minimum inhibitory concentration (AUC/MIC) ≥400 and also to obtain trough serum concentration of vancomycin of ≥15 mg/L, it is necessary to individualize doses of vancomycin in critically ill patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shahrami, Bita& Najmeddin, Farhad& Mousavi, Sarah& Ahmadi, Arezoo& Rouini, Mohammad Reza& Sadeghi, Kourosh…[et al.]. 2016. Achievement of Vancomycin Therapeutic Goals in Critically Ill Patients: Early Individualization May Be Beneficial. Critical Care Research and Practice،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099506
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shahrami, Bita…[et al.]. Achievement of Vancomycin Therapeutic Goals in Critically Ill Patients: Early Individualization May Be Beneficial. Critical Care Research and Practice No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1099506
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shahrami, Bita& Najmeddin, Farhad& Mousavi, Sarah& Ahmadi, Arezoo& Rouini, Mohammad Reza& Sadeghi, Kourosh…[et al.]. Achievement of Vancomycin Therapeutic Goals in Critically Ill Patients: Early Individualization May Be Beneficial. Critical Care Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099506
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1099506
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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