Achievement of Vancomycin Therapeutic Goals in Critically Ill Patients: Early Individualization May Be Beneficial
Joint Authors
Mousavi, Sarah
Shahrami, Bita
Najmeddin, Farhad
Ahmadi, Arezoo
Rouini, Mohammad Reza
Sadeghi, Kourosh
Mojtahedzadeh, Mojtaba
Source
Critical Care Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
The aim of our study was to assess and validate the effectiveness of early dose adjustment of vancomycin based on first dose monitoring in achieving target recommended goal in critically ill patients.
Methods.
Twenty critically ill patients with sepsis received loading dose of 25 mg/kg of vancomycin and then were randomly assigned to 2 groups.
Group 1 received maximum empirical doses of vancomycin of 15 mg/kg every 8 hrs.
In group 2, the doses were individualized based on serum concentrations of vancomycin.
First dose nonsteady state sampling was used to calculate pharmacokinetic parameters of the patients within 24 hours.
Results.
Steady state trough serum concentrations were significantly higher in group 2 in comparison with group 1 (19.4 ± 4.4 mg/L versus 14.4 ± 4.3 mg/L) (P=0.03).
Steady state AUCs were significantly higher in group 2 compared with group 1 (665.9 ± 136.5 mg·hr/L versus 490.7 ± 101.1 mg·hr/L) (P=0.008).
Conclusions.
With early individualized dosing regimen, significantly more patients achieved peak and trough steady state concentrations.
In the context of pharmacokinetic/pharmacodynamic goal of area under the time concentration curve to minimum inhibitory concentration (AUC/MIC) ≥400 and also to obtain trough serum concentration of vancomycin of ≥15 mg/L, it is necessary to individualize doses of vancomycin in critically ill patients.
American Psychological Association (APA)
Shahrami, Bita& Najmeddin, Farhad& Mousavi, Sarah& Ahmadi, Arezoo& Rouini, Mohammad Reza& Sadeghi, Kourosh…[et al.]. 2016. Achievement of Vancomycin Therapeutic Goals in Critically Ill Patients: Early Individualization May Be Beneficial. Critical Care Research and Practice،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099506
Modern Language Association (MLA)
Shahrami, Bita…[et al.]. Achievement of Vancomycin Therapeutic Goals in Critically Ill Patients: Early Individualization May Be Beneficial. Critical Care Research and Practice No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1099506
American Medical Association (AMA)
Shahrami, Bita& Najmeddin, Farhad& Mousavi, Sarah& Ahmadi, Arezoo& Rouini, Mohammad Reza& Sadeghi, Kourosh…[et al.]. Achievement of Vancomycin Therapeutic Goals in Critically Ill Patients: Early Individualization May Be Beneficial. Critical Care Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099506
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099506