![](/images/graphics-bg.png)
Domperidone Prescribing Practices Exposed Patients to Cardiac Risk despite a “Black Box” Warning: A Canadian Tertiary Care Center Study
المؤلفون المشاركون
Forbes, Nauzer
Cooray, Mohan
Al-Dabbagh, Raed
Yuan, Yuhong
Liu, Louis W. C.
Xenodemetropoulos, Ted
Tse, France
المصدر
Canadian Journal of Gastroenterology and Hepatology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-24
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
In 2012, Health Canada released a warning regarding domperidone use, based on associations with life-threatening arrhythmias and death.
Objective.
This study aimed to compare the appropriateness of domperidone prescribing patterns before the advisory to those afterward.
Methods.
Two retrospective reviews were conducted for patients prescribed domperidone during quarters in 2005 and 2012.
Outcomes included appropriateness of indication, dosing regimens, monitoring of electrolytes, baseline electrocardiogram performance and characteristics, presence of left ventricular dysfunction, and coprescription of QT-prolonging medications.
Univariable and multivariable logistic regression analyses were performed.
p values < 0.05 were considered significant.
Results.
290 and 287 patients were analyzed in 2005 and 2012, respectively.
Domperidone initiation in hospital decreased from 2005 to 2012 (71.4% versus 39.4%, p < 0.0001 ) as did prescriptions for nonapproved indications (84.8% versus 58.2%, p < 0.0001 ).
In-hospital initiation predicted prescription for nonapproved indications (OR = 7.01, 95% CI 4.52–10.87, p < 0.0001 ).
Use of domperidone as the sole GI drug predicted nonapproved indications (OR = 2.51, 95% CI 1.38–4.55, p = 0.002 ).
Conclusions.
The advisory was associated with more appropriate domperidone initiation and compliance with recommended dosages.
Our study suggests the need for increased awareness of the dosing and monitoring of domperidone to ensure patient safety.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Forbes, Nauzer& Cooray, Mohan& Al-Dabbagh, Raed& Yuan, Yuhong& Tse, France& Liu, Louis W. C.…[et al.]. 2016. Domperidone Prescribing Practices Exposed Patients to Cardiac Risk despite a “Black Box” Warning: A Canadian Tertiary Care Center Study. Canadian Journal of Gastroenterology and Hepatology،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1099863
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Forbes, Nauzer…[et al.]. Domperidone Prescribing Practices Exposed Patients to Cardiac Risk despite a “Black Box” Warning: A Canadian Tertiary Care Center Study. Canadian Journal of Gastroenterology and Hepatology No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1099863
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Forbes, Nauzer& Cooray, Mohan& Al-Dabbagh, Raed& Yuan, Yuhong& Tse, France& Liu, Louis W. C.…[et al.]. Domperidone Prescribing Practices Exposed Patients to Cardiac Risk despite a “Black Box” Warning: A Canadian Tertiary Care Center Study. Canadian Journal of Gastroenterology and Hepatology. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1099863
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1099863
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)