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Domperidone Prescribing Practices Exposed Patients to Cardiac Risk despite a “Black Box” Warning: A Canadian Tertiary Care Center Study
Joint Authors
Forbes, Nauzer
Cooray, Mohan
Al-Dabbagh, Raed
Yuan, Yuhong
Liu, Louis W. C.
Xenodemetropoulos, Ted
Tse, France
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-24
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
In 2012, Health Canada released a warning regarding domperidone use, based on associations with life-threatening arrhythmias and death.
Objective.
This study aimed to compare the appropriateness of domperidone prescribing patterns before the advisory to those afterward.
Methods.
Two retrospective reviews were conducted for patients prescribed domperidone during quarters in 2005 and 2012.
Outcomes included appropriateness of indication, dosing regimens, monitoring of electrolytes, baseline electrocardiogram performance and characteristics, presence of left ventricular dysfunction, and coprescription of QT-prolonging medications.
Univariable and multivariable logistic regression analyses were performed.
p values < 0.05 were considered significant.
Results.
290 and 287 patients were analyzed in 2005 and 2012, respectively.
Domperidone initiation in hospital decreased from 2005 to 2012 (71.4% versus 39.4%, p < 0.0001 ) as did prescriptions for nonapproved indications (84.8% versus 58.2%, p < 0.0001 ).
In-hospital initiation predicted prescription for nonapproved indications (OR = 7.01, 95% CI 4.52–10.87, p < 0.0001 ).
Use of domperidone as the sole GI drug predicted nonapproved indications (OR = 2.51, 95% CI 1.38–4.55, p = 0.002 ).
Conclusions.
The advisory was associated with more appropriate domperidone initiation and compliance with recommended dosages.
Our study suggests the need for increased awareness of the dosing and monitoring of domperidone to ensure patient safety.
American Psychological Association (APA)
Forbes, Nauzer& Cooray, Mohan& Al-Dabbagh, Raed& Yuan, Yuhong& Tse, France& Liu, Louis W. C.…[et al.]. 2016. Domperidone Prescribing Practices Exposed Patients to Cardiac Risk despite a “Black Box” Warning: A Canadian Tertiary Care Center Study. Canadian Journal of Gastroenterology and Hepatology،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1099863
Modern Language Association (MLA)
Forbes, Nauzer…[et al.]. Domperidone Prescribing Practices Exposed Patients to Cardiac Risk despite a “Black Box” Warning: A Canadian Tertiary Care Center Study. Canadian Journal of Gastroenterology and Hepatology No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1099863
American Medical Association (AMA)
Forbes, Nauzer& Cooray, Mohan& Al-Dabbagh, Raed& Yuan, Yuhong& Tse, France& Liu, Louis W. C.…[et al.]. Domperidone Prescribing Practices Exposed Patients to Cardiac Risk despite a “Black Box” Warning: A Canadian Tertiary Care Center Study. Canadian Journal of Gastroenterology and Hepatology. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1099863
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099863