Association between NSAIDs and Clostridium difficile-Associated Diarrhea: A Systematic Review and Meta-Analysis
المؤلفون المشاركون
Permpalung, Nitipong
Upala, Sikarin
Sanguankeo, Anawin
Sornprom, Suthanya
المصدر
Canadian Journal of Gastroenterology and Hepatology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-08
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
Clostridium difficile infection is a leading cause of nosocomial diarrhea in developed countries.
Studies evaluating the associations of increased risk of community-acquired CDAD and the use of nonsteroidal anti-inflammatory drugs (NSAIDs) have yielded inconclusive results.
We conducted a systematic review and meta-analysis to compare the odds of NSAID exposure in patients with CDAD versus patients without CDAD in both community-based and healthcare-associated settings.
Methods.
Relevant observational studies indexed in PubMed/MEDLINE and EMBASE up to February 2015 were analyzed and data were extracted from nine studies.
Of these, eight studies were included in the meta-analysis.
Results.
A search of the databases resulted in 987 articles.
The nine studies from which data were extracted involved over 39,000 subjects.
The pooled odds ratio for history of NSAID use in participants with CDAD compared with controls was 1.41 (95% CI 1.06–1.87; p < 0.01 ), indicating a significant increased odds of CDAD among patients exposed to NSAIDs.
Conclusions.
To the best of our knowledge, this is the first study of its nature to demonstrate the association between the use of NSAIDs and increased risk of CDAD.
Further studies to evaluate if any specific types of NSAIDs can increase the risk of CDAD are warranted.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Permpalung, Nitipong& Upala, Sikarin& Sanguankeo, Anawin& Sornprom, Suthanya. 2016. Association between NSAIDs and Clostridium difficile-Associated Diarrhea: A Systematic Review and Meta-Analysis. Canadian Journal of Gastroenterology and Hepatology،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1099919
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Permpalung, Nitipong…[et al.]. Association between NSAIDs and Clostridium difficile-Associated Diarrhea: A Systematic Review and Meta-Analysis. Canadian Journal of Gastroenterology and Hepatology No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1099919
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Permpalung, Nitipong& Upala, Sikarin& Sanguankeo, Anawin& Sornprom, Suthanya. Association between NSAIDs and Clostridium difficile-Associated Diarrhea: A Systematic Review and Meta-Analysis. Canadian Journal of Gastroenterology and Hepatology. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1099919
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1099919
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر